Impact of Branched-chain Amino Acids in the Development of Insulin Resistance
NCT ID: NCT03261362
Last Updated: 2023-06-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2016-03-31
2019-12-31
Brief Summary
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Detailed Description
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The specific aims are to elucidate the effect of the diet induced decrease of BCAAs concentrations on (I) peripheral and hepatic insulin sensitivity (II) ectopic fat distribution (III) energy metabolism (IV) metabolic and inflammatory status
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
QUADRUPLE
Study Groups
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Amino acid powder with all amino acids
amino acid powder 80 g oral Administration 1 week
Branched-chain amino acids reduced intake
Amino acid powder without BCAAs-reduced intake
Branched-chain amino acids reduced intake - amino acid powder lacking BCAAs 80 g oral Administration 1 week -
Branched-chain amino acids reduced intake
Interventions
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Branched-chain amino acids reduced intake
Eligibility Criteria
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Inclusion Criteria
* Non smokers
* Untrained
* Willingness to adhere to a diet intervention
Exclusion Criteria
* Pregnancy
* Cancer
* Antibiotic therapy
* Drug/alcohol abuse
* Competitive athletes
30 Years
60 Years
ALL
No
Sponsors
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German Diabetes Center
OTHER
Responsible Party
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Principal Investigators
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Michael Roden, MD
Role: PRINCIPAL_INVESTIGATOR
Deutsches Diabetes Zentrum
Locations
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German Diabetes Centre
Düsseldorf, , Germany
Countries
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References
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Karusheva Y, Koessler T, Strassburger K, Markgraf D, Mastrototaro L, Jelenik T, Simon MC, Pesta D, Zaharia OP, Bodis K, Barenz F, Schmoll D, Wolkersdorfer M, Tura A, Pacini G, Burkart V, Mussig K, Szendroedi J, Roden M. Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial. Am J Clin Nutr. 2019 Nov 1;110(5):1098-1107. doi: 10.1093/ajcn/nqz191.
Other Identifiers
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2014092783
Identifier Type: -
Identifier Source: org_study_id
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