Iron Absorption and Exercise

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

31 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-22

Study Completion Date

2019-12-04

Brief Summary

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Iron is a nutritionally essential mineral required for optimal physical and cognitive performance. Endurance exercise often leads to declines in iron status; however, the reason for the decline is not known. The primary objective of the proposed study is to determine the effects of an acute bout of strenuous endurance exercise on iron absorption and status and markers of inflammation in human volunteers. The investigators hypothesize that an acute bout of strenuous endurance exercise, compared to rest, will reduce iron absorption, resulting in diminished iron status, and that reduced iron absorption will be negatively associated with markers of inflammation. A secondary objective is to monitor iron status throughout a season of competition.

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Detailed Description

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Conditions

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Iron-deficiency Iron Deficiency Anemia

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Exercise

During the exercise arm, volunteers will complete a planned workout, as prescribed by the coach. The workout will be designed to be strenuous and induce an inflammatory response.

Group Type EXPERIMENTAL

Meal

Intervention Type OTHER

Participants will consume a meal containing a stable iron isotope following exercise or rest.

Rest

The rest arm will be coordinated with a planned non-workout day, as prescribed by the coach, where volunteers are either scheduled to not run or go for an easy recovery run (\<6 miles at a self-described "easy" pace) later in the afternoon.

Group Type EXPERIMENTAL

Meal

Intervention Type OTHER

Participants will consume a meal containing a stable iron isotope following exercise or rest.

Interventions

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Meal

Participants will consume a meal containing a stable iron isotope following exercise or rest.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Members of the Florida State University Cross Country team
* Refrain from using any pain-relievers (e.g., acetaminophen, nonsteroidal anti-inflammatory drugs such as aspirin, Advil®, Aleve®, Naprosyn®), or any other aspirin-containing product on the 2 study days
* Refrain from using vitamin or mineral supplements on the study days