Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
100 participants
INTERVENTIONAL
2019-07-12
2028-04-25
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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Standard protein (control)
No interventions assigned to this group
High animal protein isolate
High animal protein isolate
Increased dietary protein content from animal protein isolates
High animal protein whole food
High animal protein whole food
Increased dietary protein content from animal protein whole food
High plant protein isolate
High plant protein isolate
Increased dietary protein content from plant protein isolates
High plant protein whole food
High plant protein whole food
Increased dietary protein content from animal protein whole food
Interventions
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High animal protein isolate
Increased dietary protein content from animal protein isolates
High animal protein whole food
Increased dietary protein content from animal protein whole food
High plant protein isolate
Increased dietary protein content from plant protein isolates
High plant protein whole food
Increased dietary protein content from animal protein whole food
Eligibility Criteria
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Inclusion Criteria
* BMI: \>24.5 and \<32.5 kg/m2;
* habitual protein intake \<0.9 g/kg/day (assessed on 2 weekdays and 2 weekend days by using the HealthWatch 360 app); and
* weight stable (i.e., ≤3% change) and untrained (≤150 min of structured exercise/week) for at least 2 months before entering the study.
Exclusion Criteria
* evidence of chronic kidney disease by medical history or laboratory tests (glomerular filtration rate \<60 ml/min/1.73 m2 or an albumin to creatinine ratio in urine ≥30 mg/g);
* vegetarians or vegans;
* intolerance or allergies to ingredients in the metabolic meal or intervention diet;
* take dietary supplements (e.g., pre- and probiotics, fiber, fish oil) or medications known to affect our study outcomes;
* received antibiotic or antifungal treatment (which affect the microbiome and therefore microbial metabolite production) 2 months before entering the study;
* consume tobacco products or excessive alcohol (women: \>14 drinks/week; men: \>21 drinks/week);
* evidence of significant organ system dysfunction or diseases (e.g., cirrhosis), and
* unwilling or unable to provide informed consent.
21 Years
70 Years
ALL
Yes
Sponsors
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University of Missouri-Columbia
OTHER
Responsible Party
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Bettina Mittendorfer
Senior Associate Dean for Research
Principal Investigators
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Bettina Mittendorfer
Role: PRINCIPAL_INVESTIGATOR
University of Missouri-Columbia
Locations
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University of Missouri School of Medicine
Columbia, Missouri, United States
Countries
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Central Contacts
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Facility Contacts
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Role: backup
Other Identifiers
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2097498
Identifier Type: -
Identifier Source: org_study_id
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