Intensive Running Exercise Improves Parkinson's Motor and Non-motor Symptoms
NCT ID: NCT03974529
Last Updated: 2019-06-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2018-12-29
2020-12-30
Brief Summary
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However, there was no evidence about regular intensive exercise of running in Parkinson's disease. And most of the studies were not randomized with a control group.
In this study, the investigators are to investigate the effect of regular vigorous aerobic exercise training of running on motor and non-motor symptoms, and quality-of-life of people with Parkinson's disease.
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Detailed Description
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One of the main complaints of Parkinson's disease is rigidity. It is because of the musculoskeletal impairments which compromise the flexibility and stability of both axial structure (spine) and the extremities. Truncal stiffness and rigidity results in a stooped posture, which further undermines one's balance and agility. Flexibility training (stretching) is shown to be beneficial to all stages of patients with Parkinson's disease, in terms of improved both range of movement in joints and spinal stability. It is recommended that regular stretching should be the first step in one's exercise program to combat the muscle rigidity. High quality clinical trial and meta-analysis have demonstrated short term, and to a lesser extent, long term benefits in various outcome measures. To achieve positive effects, supervised progressive strength and aerobic endurance training program of 12 weeks was required. Extended progressive strength training improved muscle strength for up to 24 months. While aerobic endurance training would increase walking capacity up to 16 months.
There are data suggested a threshold of intensity of exercise to be reached for the positive effect. This overall body of evidence suggests that regular vigorous exercise should be accorded a central place in the treatment of Parkinson's disease.
In this study, the investigators are to investigate the effect of regular vigorous aerobic exercise training of running on motor and non-motor symptoms, and quality-of-life of people with Parkinson's disease.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
Intervention arm
* Number of participants: 20
* Venue: Shatin playground
* Supervisors: licensed coaches (2 to 4 per session)
* Training session: 30 minutes of warm-up stretching + 60 minutes supervised progressive aerobic endurance track running
* Targeted intensity: 60-75% of maximum heart rate (HR max = 220 - age) OR 40-50% heart rate reserve (HRR= HR max - HR rest)
* Frequency and training period: 2 sessions per week, for 24 weeks
Control arm
* Number of participants: 10
* Venue: Indoor gymnasium
* Supervisor: a physiotherapist
* Training session: 60 minutes of physical stretching
* Frequency and training period: 1 session per week, for 24 weeks
TREATMENT
SINGLE
Study Groups
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Intensive running arm
20 patients will be assigned randomly to intensive running arm (intervention arm). They will be required to complete a designed training protocol.
Intensive running
The patients who are assigned to this group will be required to finish a 90 minutes of training protocol, containing 30 minutes' warm-up stretching, and 60 minutes of supervised progressive aerobic endurance track running. The training takes place two time per week, for 24 weeks.
Physiotherapy arm
10 patients will be assigned randomly to physiotherapy arm. They will be required to complete a designed training protocol.
Physiotherapy
The patients who are assigned to this group will be required to finish a 60 minutes of physiotherapy session. The training takes place once per week, for 24 weeks.
Interventions
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Intensive running
The patients who are assigned to this group will be required to finish a 90 minutes of training protocol, containing 30 minutes' warm-up stretching, and 60 minutes of supervised progressive aerobic endurance track running. The training takes place two time per week, for 24 weeks.
Physiotherapy
The patients who are assigned to this group will be required to finish a 60 minutes of physiotherapy session. The training takes place once per week, for 24 weeks.
Eligibility Criteria
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Inclusion Criteria
2. Patient who are able to walk independently without walking aids for a distance of 30 meters.
Exclusion Criteria
2. Presence of ischemic heart disease or musculoskeletal and cardiopulmonary diseases
3. Presence of physical disability
4. History of regular running practice in the past 6 months.
40 Years
60 Years
ALL
No
Sponsors
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The Hong Kong Polytechnic University
OTHER
Prince of Wales Hospital, Shatin, Hong Kong
OTHER
Chinese University of Hong Kong
OTHER
Responsible Party
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Dr. Danny Tat Ming Chan
Head of Neurosurgery, Principal Investigator, Honorary Clinical Professor
Principal Investigators
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Danny TM Chan, Dr.
Role: PRINCIPAL_INVESTIGATOR
Chinese University of Hong Kong
Locations
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The Chinese University of Hong Kong
Hong Kong, , Hong Kong
Countries
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Central Contacts
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Facility Contacts
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References
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Mak MK, Wong-Yu IS, Shen X, Chung CL. Long-term effects of exercise and physical therapy in people with Parkinson disease. Nat Rev Neurol. 2017 Nov;13(11):689-703. doi: 10.1038/nrneurol.2017.128. Epub 2017 Oct 13.
Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Apr 8;4(4):CD013856. doi: 10.1002/14651858.CD013856.pub3.
Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Jan 5;1(1):CD013856. doi: 10.1002/14651858.CD013856.pub2.
Provided Documents
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Document Type: Study Protocol
Document Type: Informed Consent Form
Related Links
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Key Citation PARKINSON ' S DISEASE A Comprehensive Approach to Exercise
Key Citation: Parkinson's disease: fitness counts
Other Identifiers
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NTEC-2018-0330
Identifier Type: REGISTRY
Identifier Source: secondary_id
Run for PD -v1
Identifier Type: -
Identifier Source: org_study_id
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