Resistance Training in Patients With Parkinson's Disease.

NCT ID: NCT02447146

Last Updated: 2015-05-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2014-12-31

Brief Summary

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This is a controlled trial to assess the effects of resistance training on bradykinesia and physical function in patients with Parkinson's Disease. Forty patients diagnosed with Parkinson Disease stage 1 to 3 of the Hoehn and Yahr scale took part in the study and were allocated into 2 groups; Training Group performed a 9-week RT program twice a week while the Control Group attended lectures on the disease.

Detailed Description

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Conditions

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Parkinson Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Training group

9-week resistance training program

Group Type EXPERIMENTAL

Resistance Training

Intervention Type OTHER

The TG performed the RT program using weight machines. Before the training period, participants underwent three weeks with eight familiarization sessions to ensure proper technique execution. The protocol aimed to workout major muscle groups and involved the following exercises: chest press, knee extension, hamstrings curl, leg press, and seated row. Training sessions lasted approximately 50-60 minutes with 2 sets of 10-12 repetitions until fatigue.

Control group

'Lectures on the disease'

Group Type OTHER

Lectures on the disease

Intervention Type OTHER

The control group attended an orientation program with lectures on health, quality of life and scientific update on disease.

Interventions

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Resistance Training

The TG performed the RT program using weight machines. Before the training period, participants underwent three weeks with eight familiarization sessions to ensure proper technique execution. The protocol aimed to workout major muscle groups and involved the following exercises: chest press, knee extension, hamstrings curl, leg press, and seated row. Training sessions lasted approximately 50-60 minutes with 2 sets of 10-12 repetitions until fatigue.

Intervention Type OTHER

Lectures on the disease

The control group attended an orientation program with lectures on health, quality of life and scientific update on disease.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Medical neurologist confirmation of 1-3 Hoehn and Yahr stages,
* age between 50 and 80 years old;
* and physician attested to participate in the resistance training program.

Exclusion Criteria

* Diagnostic of any other neurological disease, cardiovascular disease, hematologic or orthopedic disorders;
* and motor fluctuations or severe dyskinesia that could affect their ability to perform the experimental protocol.
Minimum Eligible Age

50 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Brasilia

OTHER

Sponsor Role lead

Responsible Party

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Wagner Rodrigues Martins

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ricardo Oliveira, PhD

Role: STUDY_DIRECTOR

College of Physical Education - University of Brasilia

References

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Dibble LE, Hale TF, Marcus RL, Droge J, Gerber JP, LaStayo PC. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's disease. Mov Disord. 2006 Sep;21(9):1444-52. doi: 10.1002/mds.20997.

Reference Type BACKGROUND
PMID: 16773643 (View on PubMed)

Falvo MJ, Sirevaag EJ, Rohrbaugh JW, Earhart GM. Resistance training induces supraspinal adaptations: evidence from movement-related cortical potentials. Eur J Appl Physiol. 2010 Jul;109(5):923-33. doi: 10.1007/s00421-010-1432-8. Epub 2010 Mar 21.

Reference Type BACKGROUND
PMID: 20306270 (View on PubMed)

Fisher BE, Wu AD, Salem GJ, Song J, Lin CH, Yip J, Cen S, Gordon J, Jakowec M, Petzinger G. The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease. Arch Phys Med Rehabil. 2008 Jul;89(7):1221-9. doi: 10.1016/j.apmr.2008.01.013. Epub 2008 Jun 13.

Reference Type BACKGROUND
PMID: 18534554 (View on PubMed)

Allen NE, Canning CG, Sherrington C, Fung VS. Bradykinesia, muscle weakness and reduced muscle power in Parkinson's disease. Mov Disord. 2009 Jul 15;24(9):1344-51. doi: 10.1002/mds.22609.

Reference Type RESULT
PMID: 19425085 (View on PubMed)

Other Identifiers

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RT-PD

Identifier Type: -

Identifier Source: org_study_id

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