Facilitating Motor Skill Learning in Parkinson's Disease III
NCT ID: NCT04653285
Last Updated: 2024-12-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
24 participants
INTERVENTIONAL
2022-07-01
2024-04-15
Brief Summary
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Detailed Description
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Thus, it is crucial to identify strategies to enhance motor learning in people with PD. Recent studies have accumulated evidence to show that acute (single bouts of) and chronic (multiple bouts of) cardiovascular exercise can facilitate motor skill learning. However, this evidence is mainly derived from studying healthy individuals. In a first study including PD patients, the investigators recently found improved motor memory consolidation, but not improved skill acquisition, when practice was preceded by a single bout of cardiovascular exercise.
These results suggested that acute exercise may enhance motor memory formation processes, but could potentially interfere with motor skill acquisition when performed prior to practice. Consequently, in a second study the investigators examined whether performing a single bout of cardiovascular exercise immediately following skill practice would enhance motor memory consolidation without affecting skill acquisition in PD. The results of this second study suggested that even a single moderate intense bout performed immediately following skill practice improves motor memory consolidation in PD patients.
Going onward from the previous two studies, the present study will investigate the effects of performing cardiovascular exercise immediately following skill practice over the course of a six week intervention period on motor memory consolidation. It will be examined how the regular direct coupling of motor learning skill practice and cardiovascular exercise influences the consolidation and automation of the practiced movements.
In an experimental trial, participants will be randomly allocated to one of two groups. Both groups will practice balancing on a stability platform (motor learning task). The experimental group will additionally perform a bout of aerobic exercise (cycle ergometer) immediately following motor practice, while the control group will rest. This intervention will be held over a period of six weeks. Subsequently, motor skill retention will be tested seven days after the last training session.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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motor skill practice + aerobic exercise
bout of aerobic exercise following motor skill practice
motor skill practice
Motor learning task on a stability platform (stabilometer). Participants try to keep the tiltable platform in a horizontal position in trials of 30s.
aerobic exercise
A bout of moderate intensity aerobic exercise on a cycle ergometer following motor skill practice.
motor skill practice + rest
seated rest following motor skill practice
motor skill practice
Motor learning task on a stability platform (stabilometer). Participants try to keep the tiltable platform in a horizontal position in trials of 30s.
rest
Seated rest following motor skill practice.
Interventions
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motor skill practice
Motor learning task on a stability platform (stabilometer). Participants try to keep the tiltable platform in a horizontal position in trials of 30s.
aerobic exercise
A bout of moderate intensity aerobic exercise on a cycle ergometer following motor skill practice.
rest
Seated rest following motor skill practice.
Eligibility Criteria
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Inclusion Criteria
* Ability to stand unaided and walk without an assistive device
* Stable medication during the study period
* Unfamiliar to the motor task (stabilometer)
Exclusion Criteria
* Unstable medical or psychiatric illness
* Clinically relevant cardiovascular or orthopaedic disease
* Severe polyneuropathy
* Cognitive impairment
* Smoking \> 10 cigarettes/day
* Caffeine \> 6 cups of coffee/day
* Alcohol \> 50 g (two glasses)/day
18 Years
85 Years
ALL
No
Sponsors
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German Foundation for Neurology
OTHER
Klinik für Neurologie, Klinikum Würzburg Mitte, Standort Juliusspital
UNKNOWN
University of Erlangen-Nürnberg
OTHER
Responsible Party
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Simon Steib, PhD
Principal Investigator
Principal Investigators
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Simon Steib, Dr.
Role: PRINCIPAL_INVESTIGATOR
Institute of Sport and Sport Science, Heidelberg University
Locations
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Heidelberg University, Institute of Sport and Sport Science, Im Neuenheimer Feld 720
Heidelberg, Bade-Wuerttemberg, Germany
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Related Links
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Other Identifiers
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DSN-2020
Identifier Type: -
Identifier Source: org_study_id