Facilitating Motor Skill Learning in Parkinson's Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-01

Study Completion Date

2018-09-30

Brief Summary

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The study is designed to assess the effects of aerobic exercise on motor learning in Parkinson patients. Specifically, the investigators examine whether a single bout of moderate intensity aerobic exercise, performed immediately before task practice, facilitates the acquisition and retention of a motor skill. In a cross-over design, participants will be randomly allocated to either the intervention group (aerobic exercise before motor learning) or control group (rest before motor learning).

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Detailed Description

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Parkinson's disease is a progressive neurodegenerative disorder that is characterized by motor control impairments, such as gait disturbances and postural instability. Beneficial effects of exercise are attributed to mechanisms of neuroplasticity, and task-specific motor training is consequently considered to be a motor learning process. While motor learning is preserved in persons with Parkinson's disease, slower acquisition rates and reduced retention have been reported compared to healthy individuals.

Thus, it is crucial to identify strategies to enhance motor learning in people with Parkinson's disease. Recent studies have accumulated evidence to show that aerobic exercise can facilitate motor skill learning. However, these observations are limited to healthy individuals and have not been addressed in individuals with neurologic conditions.

The present study is designed to assess the effects of a single bout of moderate intensity aerobic exercise on a motor skill learning task in patients with Parkinson's disease.

In a cross-over design, participants will be randomly allocated to one of two groups. Both groups will practice balancing on a specific stability platform (motor learning task). The experimental group will additionally perform a bout of aerobic exercise (cycle ergometer) immediately before the motor learning task, while the control group will rest before practice. Subsequently, the acquisition and one-day retention of the motor learning task will be examined.

Conditions

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Parkinson Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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aerobic exercise + motor skill practice

acute bout of aerobic exercise before motor learning

Group Type EXPERIMENTAL

aerobic exercise

Intervention Type BEHAVIORAL

Single-bout of moderate intensity aerobic exercise on a cycle ergometer before motor learning

motor learning

Intervention Type BEHAVIORAL

Motor learning task on a stability platform (Stabilometer). Participants try to keep the tiltable platform in an horizontal position.

rest + motor skill practice

seated rest before motor learning

Group Type ACTIVE_COMPARATOR

rest

Intervention Type BEHAVIORAL

Seated rest before motor learning

motor learning

Intervention Type BEHAVIORAL

Motor learning task on a stability platform (Stabilometer). Participants try to keep the tiltable platform in an horizontal position.

Interventions

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aerobic exercise

Single-bout of moderate intensity aerobic exercise on a cycle ergometer before motor learning

Intervention Type BEHAVIORAL

rest

Seated rest before motor learning

Intervention Type BEHAVIORAL

motor learning

Motor learning task on a stability platform (Stabilometer). Participants try to keep the tiltable platform in an horizontal position.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Parkinson's disease stage 1-3 on Hoehn \& Yahr scale
* Ability to stand unaided and walk without an assistive device
* Stable medication during the study period

Exclusion Criteria

* On-off and wearing-off phenomena
* Unstable medical or psychiatric illness
* Clinically relevant cardiovascular or orthopaedic disease
* Severe polyneuropathy
* Cognitive impairment
* Smoking \> 10 cigarettes/day
* Caffeine \> 6 cups of coffee/day
* Alcohol \> 50 g (two glasses)/day

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No