Facilitating Motor Skill Learning in Parkinson's Disease II (FaST-PD II)
NCT ID: NCT03886090
Last Updated: 2020-03-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
18 participants
INTERVENTIONAL
2019-01-01
2020-02-24
Brief Summary
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Detailed Description
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Thus, it is crucial to identify strategies to enhance motor learning in people with PD. Recent studies have accumulated evidence to show that acute (single bouts of) cardiovascular exercise can facilitate motor skill learning. However, this evidence is mainly derived from studying healthy individuals. In a first study including PD patients, we recently found improved motor memory consolidation, but not skill acquisition, when practice was preceded by a single bout of cardiovascular exercise.
These results suggest that acute exercise may enhance motor memory formation processes, but could potentially interfere with motor skill acquisition when performed prior to practice. Consequently, the present study investigates whether performing a single bout of cardiovascular exercise immediately following skill practice will enhance motor memory consolidation without affecting skill acquisition in PD.
In an experimental trial, participants will be randomly allocated to one of two groups. Both groups will practice balancing on a stability platform (motor learning task). The experimental group will additionally perform a bout of aerobic exercise (cycle ergometer) immediately following motor practice, while the control group will rest. Subsequently, motor skill retention will be tested after 24 hour and seven-days.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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motor skill practice + aerobic exercise
acute bout of aerobic exercise following motor skill practice
aerobic exercise
Single-bout of moderate intensity aerobic exercise on a cycle ergometer following motor skill practice
motor learning
Motor learning task on a stability platform (Stabilometer). Participants try to keep the tiltable platform in a horizontal position.
motor skill practice + rest
seated rest following motor skill practice
rest
Seated rest following motor skill practice
motor learning
Motor learning task on a stability platform (Stabilometer). Participants try to keep the tiltable platform in a horizontal position.
Interventions
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aerobic exercise
Single-bout of moderate intensity aerobic exercise on a cycle ergometer following motor skill practice
rest
Seated rest following motor skill practice
motor learning
Motor learning task on a stability platform (Stabilometer). Participants try to keep the tiltable platform in a horizontal position.
Eligibility Criteria
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Inclusion Criteria
* Ability to stand unaided and walk without an assistive device
* Stable medication during the study period
* Unfamiliar to the motor learning task
Exclusion Criteria
* Unstable medical or psychiatric illness
* Clinically relevant cardiovascular or orthopaedic disease
* Severe polyneuropathy
* Cognitive impairment
* Smoking \> 10 cigarettes/day
* Caffeine \> 6 cups of coffee/day
* Alcohol \> 50 g (two glasses)/day
18 Years
ALL
No
Sponsors
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German Foundation for Neurology
OTHER
Department of Molecular Neurology, Faculty of Medicine, University Erlangen-Nürnberg
OTHER
Klinik für Neurologie, Krankenhaus Rummelsberg
UNKNOWN
University of Erlangen-Nürnberg
OTHER
Responsible Party
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Simon Steib, PhD
Principal Investigator
Principal Investigators
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Simon Steib, Dr.
Role: PRINCIPAL_INVESTIGATOR
Friedrich-Alexander University Erlangen-Nürnberg, Department of Sport Science and Sport
Locations
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Friedrich-Alexander University Erlangen-Nürnberg, Department of Sport Science and Sport, Gebbertstr. 123b
Erlangen, Bavaria, Germany
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Related Links
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Other Identifiers
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DSN-2018
Identifier Type: -
Identifier Source: org_study_id
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