Embryo DNA Repair Capacity Project

NCT ID: NCT03953859

Last Updated: 2022-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

6 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-04-04

Study Completion Date

2021-12-09

Brief Summary

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The mail aim of the present study is to use molecular methods to analyze the ability of human preimplantation embryos to repair their DNA

Detailed Description

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The main aim of the present study is to investigate the DNA repair pathways of preimplantation embryos, examining the events that take place following induction of a DSB at a unique targeted site. The investigators aim to address questions concerning the functionality of the DNA repair mechanism(s) in developing embryos, before and after genome activation.

Conditions

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Infertility

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Gamete donors

healthy male and female game donors to undergo routine gamete donation process

double strand break

Intervention Type GENETIC

an induction of a double strand break will be made in the embryos generated for this research and the repair mechanism observed

Infertile Couple

Couples undergoing routine IVF to treat their infertility

No interventions assigned to this group

Interventions

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double strand break

an induction of a double strand break will be made in the embryos generated for this research and the repair mechanism observed

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* gamete donors: be at least 21 years of age, in good health and eligible to donate their games through the standard gamete donation programs
* IVF couples: any couples proceeding with a routine IVF cycle

Exclusion Criteria

* less than 21 years of age
* inability to provide informed consent
Minimum Eligible Age

21 Years

Maximum Eligible Age

42 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Reproductive Medicine Associates of New Jersey

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Reproductive Medicine Assoicates of New Jersey

Basking Ridge, New Jersey, United States

Site Status

Countries

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United States

Other Identifiers

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RMA-UK-01

Identifier Type: -

Identifier Source: org_study_id

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