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Geneexpression as a Marker of Embryo Viability

NCT ID: NCT02399787

Last Updated: 2020-11-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-04-30

Study Completion Date

2020-05-01

Brief Summary

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The aim of the post doc project is investigate which genes regulate implantation in order to analyze specific proteins and microRNA in the spent culture media with the long-term goal of developing a non-invasive method of embryo assessment and selection. This will be achieved by conducting a targeted NGS analysis, based on list obtained from a non-published pilot study. When further validated by q-PCR, the expression of specific microRNAs known to influence the final list of genes will be analyzed in the spent culture media and the protein products of the genes recovered from the media will be quantified. The level of specific microRNAs and proteins will be related to aneuploidy and implantation potential. If the level of specific microRNA and/or proteins correlates with pregnancy, the study will form the basis for developing a clinical applicable precise method of improved embryo selection and thus improved IVF treatment.

Detailed Description

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Conditions

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Infertility

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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infertile patients

Infertile patients with more than 5 oocytes retrieved and no endometriosis

blastocyst biopsy

Intervention Type OTHER

Performed on day 5

Interventions

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blastocyst biopsy

Performed on day 5

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* \>5 oocytes retrieved

Exclusion Criteria

* endometriosis
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aarhus University Hospital

OTHER

Sponsor Role collaborator

University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Kirstine Kirkegaard

post doc

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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The Fertility Clinic, Aarhus University Hospital, Skejby

Aarhus, , Denmark

Site Status

Countries

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Denmark

Related Links

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https://pubmed.ncbi.nlm.nih.gov/32681282/

publication of results

Other Identifiers

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1-10-72-382-13

Identifier Type: -

Identifier Source: org_study_id