Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
60 participants
INTERVENTIONAL
2019-03-06
2019-09-10
Brief Summary
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Detailed Description
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Levosimendan is an inodilator which exerts its positive inotropic effect by enhancing the sensitivity of troponin C to calcium without increasing intracellular calcium concentration. Levosimendan also decreases the systemic vascular resistance, so, it increases the cardiac output without increasing myocardial oxygen consumption.
This study aims to compare the efficacy of Levosimendan versus Milrinone in supporting hemodynamics during off-pump coronary artery bypass grafting surgery in patients with low ejection fraction.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Levosimendan
Intraoperative infusion of Levosimendan
Levosimendan
Intraoperative infusion of Levosimendan
Milrinone
Intraoperative infusion of Milrinone
Milrinone
Intraoperative infusion of Milrinone
Interventions
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Levosimendan
Intraoperative infusion of Levosimendan
Milrinone
Intraoperative infusion of Milrinone
Eligibility Criteria
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Inclusion Criteria
* ejection fraction \< 50%
Exclusion Criteria
* Patients on mechanical support (intra-aortic balloon pump)
30 Years
80 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Hany Mostafa Esmaeil Osman
Principal Investigator
Locations
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Assiut University
Asyut, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Levosimendan, Milrinone, CABG
Identifier Type: -
Identifier Source: org_study_id
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