Exercise Oxygen Kinetic and Cardiac Output in Hypertrophic Cardiomyopathy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-20

Study Completion Date

2024-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Fatigue and dyspnea that reduce exercise performance are common symptoms in patients with hypertrophic cardiomyopathy. Since the cause of this functional limitation has not yet been described, this study aims to evaluate the cardiopulmonary parameters measured at cardiopulmonary exercise test in combination with those obtained by non-invasive measurement of cardiac output by impedance (Physioflow) and echocardiography. These results will help to better define the mechanisms underlying limitation in these patients, also in relation to the degree of LVOT obstruction.

The aim of the present study is to assess the cardiopulmonary response to exercise in patients with hypertrophic cardiomyopathy, based on the degree of LVOT obstruction, by adding non-invasive measurement of cardiac output by Physioflow and echocardiographic parameters to the cardiopulmonary exercise test parameters associated with stroke volume and cardiac output (ie. VO2/WR, O2pulse) Consecutive patients with a previous diagnosis of hypertrophic cardiomyopathy on optimised medical therapy will be enrolled to perform a cardiopulmonary exercise test with simultaneous measurement of cardiac output and an exercise echocardiogram for clinical routine.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Neurohormonal Parameters in Hypertrophic Cardiomyopathies

NCT01729702

1- Primary (Sarcomeric) Hypertrophic Cardiomyopathy 2- Obstructive Hypertrophic Cardiomyopathy 3- Non Obstructive Hypertrophic Cardiomyopathy

COMPLETED NA

Contrast Echocardiography During Exercise to Assess Pulmonary Blood Volume

NCT06195059

Heart Failure Pulmonary Vascular Disease

RECRUITING

Discontinuous Echocardiographic Subcostal Cardiac Output Measurement

NCT07177391

Cardiac Output Measurement

RECRUITING

Cardiovascular, Pulmonary and Skeletal Muscle Evaluation Postoperative in Fontan Patients: Effects of Exercise Training

NCT02283255

Congenital Heart Disease Single Ventricle Univentricular Heart

COMPLETED NA

Echocardiographic Assessment and CLInical imPlication of Functional tricuSpid rEgurgitation in Heart Failure With Reduced or Preserved Ejection Fraction

NCT05209919

Functional Tricuspid Regurgitation

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cardiopulmonary Exercise Test Hypertrophic Cardiomyopathy Cardiac Output Measurement

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* hypertrophic cardiomyopathy diagnosis

Exclusion Criteria

* use of long-term oxygen therapy;
* presence of comorbidities affecting the ability to perform cardiopulmonary exercise test or interfering with exercise performance;
* concomitant at least moderate chronic obstructive pulmonary disease

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No