Right Ventricular Function During Exercise in Highlanders/Lowlanders

NCT ID: NCT03165032

Last Updated: 2019-08-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

173 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-05-24

Study Completion Date

2017-08-16

Brief Summary

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The purpose of the current study is to evaluate the right ventricular function during graded cycling on an ergometer by transthoracic echocardiography in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross-sectional case-control study.

Detailed Description

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Conditions

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High Altitude Pulmonary Hypertension

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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High altitude pulmonary hypertension

Highlanders with high altitude pulmonary hypertension living above 2500 m.

No interventions assigned to this group

High altitude control

Healthy highlanders living above 2500 m.

No interventions assigned to this group

Low altitude control

Healthy lowlanders living below 1000 m.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* high altitude pulmonary hypertension confirmed by clinical presentation and mean pulmonary artery pressure \>30 mmHg measured by echocardiography at altitude of residence.
* healthy subjects (high altitude controls)
* Both genders
* Age \>16 y
* Kyrgyz ethnicity
* born, raised and currently living at \>2500 m
* healthy subjects currently living at \<1000 m (low altitude controls)

Exclusion Criteria

* Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
* Excessive erythrocytosis
* Other coexistent disorders that may interfere with the cardio-respiratory system and sleep
* Regular use of medication that affects control of breathing
* Heavy smoking
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov

OTHER_GOV

Sponsor Role collaborator

University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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Silvia Ulrich Somaini

Prof. Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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National Center for Cardiology and Internal Medicine

Bishkek, , Kyrgyzstan

Site Status

Countries

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Kyrgyzstan

Other Identifiers

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01-8/433B

Identifier Type: -

Identifier Source: org_study_id

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