Right Ventricular Function at Rest in Highlanders/Lowlanders

NCT ID: NCT03165656

Last Updated: 2019-08-16

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 173 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-05-24
• Study Completion Date: 2017-08-16

Brief Summary

The purpose of the current study is to evaluate the progression of right ventricular function and dimension in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross sectional case-control study.

Conditions

High Altitude Pulmonary Hypertension

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

High altitude pulmonary hypertension

Highlanders with high altitude pulmonary hypertension living above 2500 m.

No interventions assigned to this group

High altitude control

Healthy highlanders living above 2500 m.

No interventions assigned to this group

Low altitude control

Healthy lowlanders living below 1000 m.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• high altitude pulmonary hypertension confirmed by clinical presentation and mean pulmonary artery pressure >30 mmHg measured by echocardiography at altitude of residence.
• healthy subjects (high altitude controls)
• Both genders
• Age >16 y
• Kyrgyz ethnicity
• born, raised and currently living at >2500 m
• healthy subjects currently living at <1000 m (low altitude controls)

Exclusion Criteria

• Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
• Excessive erythrocytosis
• Other coexistent disorders that may interfere with the cardio-respiratory system and sleep
• Regular use of medication that affects control of breathing
• Heavy smoking

• Minimum Eligible Age: 16 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov

OTHER_GOV

Sponsor Role: collaborator

University of Zurich

OTHER

Sponsor Role: lead

Responsible Party

Silvia Ulrich Somaini

Prof. Dr.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Talant M Sooronbaev, MD

Role: STUDY_CHAIR

National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan

Locations

National Center for Cardiology and Internal Medicine

Bishkek, , Kyrgyzstan

Countries

Kyrgyzstan

References

Gosens R, Hiemstra PS, Adcock IM, Bracke KR, Dickson RP, Hansbro PM, Krauss-Etschmann S, Smits HH, Stassen FRM, Bartel S. Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease. Eur Respir J. 2020 Aug 20;56(2):1902320. doi: 10.1183/13993003.02320-2019. Print 2020 Aug.

Reference Type: DERIVED

PMID: 32430415 (View on PubMed)

Other Identifiers

01-8/433A

Identifier Type: -

Identifier Source: org_study_id