Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
90 participants
OBSERVATIONAL
2014-08-31
2017-06-30
Brief Summary
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Today, the most often used comprehensive non-invasive method for these purposes is echocardiography. However, the method has limitations; in many cases PAP is significantly under- or overestimated - especially in subjects with co-existing pulmonary diseases. Regarding right ventricular function, although novel echocardiography parameters appear to be promising, they have not yet been evaluated in all forms of PH.
Another emerging non-invasive method is cardiac magnetic resonance imaging (MRI). MRI is considered to be as gold standard for the non-invasive assessment of right ventricular function. In addition, our group showed that with a special approach ("vortex method"), MRI enables the determination of PAP with physiologic accuracy, but the method has not yet been validated systematically in different forms of PH.
All patients undergoing right heart catheterization in our clinic are candidates for the study. Excluded will be patients not eligible for MRI or declining to take part in the study. MRI and Echocardiography will be performed within two weeks of the RHC.
Hypothesis:
1. MRI is superior to echocardiography to non-invasively determine mean PAP in a broad collective of patients with PH of diverse ethology.
2. MRI derived right ventricular functional parameters correlate better to invasive measurements and to established prognostic parameters than echocardiography derived right ventricular functional parameters.
3. Novel right ventricular tissue Doppler parameters add substantially to "classical" echocardiography parameters to describe right ventricular function.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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right heart catheterization patients
No interventions assigned to this group
Eligibility Criteria
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Exclusion Criteria
18 Years
99 Years
ALL
No
Sponsors
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National Bank of Austria
OTHER_GOV
Ludwig Boltzmann Institute for Lung Vascular Research
OTHER
Medical University of Graz
OTHER
Responsible Party
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Principal Investigators
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Horst Olschewski, Prof.
Role: PRINCIPAL_INVESTIGATOR
Medical University of Graz
Locations
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Medical University of Graz
Graz, , Austria
Countries
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Other Identifiers
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25-593 ex 12/13
Identifier Type: -
Identifier Source: org_study_id
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