3D Echocardiographic Assessment of RV Function in Patients Undergoing Pulmonary Endarterectomy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

51 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-05-31

Study Completion Date

2016-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Chronic thromboembolic pulmonary hypertension causes progressive right heart hypertrophy, dilatation and dysfunction. Surgical treatment is pulmonary endarterectomy, which although only carried out in a single UK centre, provides an excellent model for assessing right ventricular function. Right heart function is most commonly assessed using echocardiography, either transthoracic pre- and post-operatively, or transoesophageal intra-operatively. Measurement of tricuspid annular plane systolic excursion is the best validated and most commonly performed measurement for right heart function, however it may be inaccurate after sternotomy and pericardial opening, making accurate assessment difficult immediately after surgery. Therefore, we aim to compare established methods of assessing right heart function with 3-dimensional echocardiographic reconstruction of the ventricle, using a novel reconstruction mechanism. Right ventricular function will be assessed in 51 patients who undergo pulmonary endarterectomy surgery at baseline, after the pericardium has been opened, following the surgical procedure, using transoesophageal echocardiography, and at six-month outpatient followup using transthoracic echocardiography, as 3D-reconstruction is valid using both modalities. This comparison should allow the investigators to determine whether such a method could replace current measurement parameters for assessment of right ventricular function, which is important for clinical management of patients in a variety of settings.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Determinants of Right Heart Remodeling in Patients With CTEPH or PAH

NCT03205085

Chronic Thrombo-embolic Pulmonary Hypertension and Pulmonary Arterial Hypertension

UNKNOWN NA

Prognosis of Right Ventricular Dysfunction Assessed by Speckle Tracking in Postoperative Thoracic Surgery

NCT05060302

Right Ventricle Thoracic Surgery

UNKNOWN NA

ADOPT: Improving Diagnosis of Pulmonary Hypertension With AI and Echo

NCT06145880

Pulmonary Hypertension

WITHDRAWN

Right Ventricular Dysfunction in Ventilated Patients With COVID-19

NCT04764032

Covid19 Right Ventricular Dysfunction ARDS

UNKNOWN

Evaluation of the Right Ventricular Systolic Function Using Real-time Three-dimensional Echocardiography in Intensive Care Unit Patients

NCT04222764

Ventricular Dysfunction, Right Lung Diseases Intensive Care Units

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Chronic Thromboembolic Pulmonary Hypertension

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Pulmonary Endarterectomy patients

Patients undergoing pulmonary endarterectomy surgery at Papworth Hospital

Pulmonary endarterectomy

Intervention Type PROCEDURE

Echocardiographic assessment right ventricular function prior to, during, and following Pulmonary Endarterectomy surgery.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Pulmonary endarterectomy

Echocardiographic assessment right ventricular function prior to, during, and following Pulmonary Endarterectomy surgery.

Intervention Type PROCEDURE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Transoesophageal Echocardiography Transthoracic Echocardiography

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adult patients
* undergoing pulmonary endarterectomy surgery at Papworth Hospital
* Willing to provide informed consent

Exclusion Criteria

* Patient refusal
* Contraindication to transoesophageal echocardiography
* Technical difficulty preventing adequate echocardiographic assessment of right heart function

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No