Prognosis Factors of Cardiac Complications After Liver Transplantation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

565 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-31

Study Completion Date

2018-01-29

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a prospective, multicenter, non-interventional, observational study of a cohort with a biological plasma and urine samples collection for the study of prognosis factors of cardiac complications after liver transplantation

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Study of Prognostic Factors in Interventional Rhythmology

NCT03099057

Cardiac Surgery

TERMINATED

Cardiac Functions in Living Donor Liver Transplant Recipients. An Echocardiographic Study.

NCT01840514

Liver Transplant

UNKNOWN

Prognosis of Isolated Left Ventricular Non-compaction in Adults

NCT02885363

Left Ventricular Non Compaction

COMPLETED NA

Strain Analysis for Assessment of Myocardic Dysfunction During Orthotopic Liver Transplantation

NCT05037838

Myocardial Dysfunction Liver Transplant; Complications

COMPLETED

Prospective Study of Heart Failure With Preserved Left Ventricular Ejection Fraction

NCT01091467

Congestive Heart Failure Left Ventricular Ejection Fraction Heart Failure With Preserved Ejection Fraction

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Liver transplantation (LT) is the standard treatment for chronic or acute hepatic insufficiency with 87% of one-year survival. Cardiovascular complications are common after LT with an incidence at 6 months ranging between 25 and 50 %. These complications are associated with significant morbidity and represents the third cause of post LT mortality. Myocardial perfusion imaging or stress echocardiography, used for preoperative cardiovascular evaluation, are not enough efficient to predict the risk of post LT cardiovascular complications. However, to improve the prediction capacity of cardiovascular disease is fundamental in order to better select the candidates for LT or to develop preventive strategies. Such a strategy could reduce the morbidity and mortality from cardiovascular diseases after LT and improve the results of LT. Cardiovascular biomarkers such as troponin or natriuretic peptide are known to be predictive factors of postoperative cardiovascular complications in non cardiac surgery. The use of biomarkers in combination with conventional tests could improve the preoperative prediction of post LT cardiovascular complications.

Hypothesis: The preoperative biomarkers dosage could improve the prediction of cardiovascular complications occurring in the year after LT.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Hepatopathy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Included patients

Patients with end-stage liver failure and registered on transplantation list.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

\- Patients older than 18 years, on list for LT because of chronic hepatic disease.

\- emergency LT, patient under guardianship or trusteeship.

Exclusion Criteria

* Patient out of list before liver transplant because of his death, his improvement, the existence of a contraindication
* Patient not presenting laboratory tests older than 1 year at the liver transplantaion.
* Patient included for over 2 years at the time of Liver transplantation.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No