Platelet Rich Fibrin VS Hyaloronic Acid in Management of Pain After Harvesting a Free Gingival Graft
NCT ID: NCT03814707
Last Updated: 2019-01-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
26 participants
INTERVENTIONAL
2019-01-10
2019-07-31
Brief Summary
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Detailed Description
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1. Case history including personal data, medical, surgical history and family history.
2. Clinical Examination.
After local infiltration of anesthesia, an adequate size of supraperiosteal recipient bed was prepared to receive the palatal graft of 15 mm mesio-distal width with 8 mm apico-coronal extension.. The free gingival graft extended from the mesial line angle upper 5 and distal line angle of upper 6 .
The coronal horizontal incision, will be 15 mm long, at least 2 mm apical from the gingival margin. A second horizontal incision will be drawn 8 mm apico coronal . Care will be taken to obtain a graft thickness of 1.5 mm. Thickness will be measured at the central point of the graft during the surgery by using an endodontic file then the grafts will be positioned, and firmly adapted to the bed, and stabilized with simple periosteal sutures.
Preparation of platelet rich fibrin:( intervention group) The classic PRF protocol was introduced by Choukroun \& coworkers. PRF requires around 10 ml of blood to be collected from the forearm of patient without anticoagulant in a glass coated plastic tubes. After collection, the blood will be quickly subjected to centrifugation at 2700-3000 rpm for 12 minutes. After the completion of cycle, the blood become separated into three distinct layers; platelet poor plasma at the top, PRF in the middle and a red blood corpuscular base in the bottom. Pliers will be inserted into the tube to gently grab the fibrin clot with attached RBC's. The clot thus obtained will be compressed to form plugs to be placed in the palatal donor site and stabilized by criss cross resorbable suture then covered by periodontal pack
control group Control group: As the intervention group but the palatal wound will receive a .2% hyaluronic acid gel then covered by periodontal dressing
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
* A randomized clinical trial.
* Parallel group study.
* A trial will be carried out in department of periodontology - Faculty of Oral and Dental medicine - Cairo University .
* Equal randomization : participants with equal probabilities for intervention.
* Positive controlled : Both groups receiving treatment.
TREATMENT
SINGLE
Study Groups
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Topical application 0.2%Hyaluronic Acid
Topical application of 0.2% hyaluronic acid gel will be placed immediately in palatal donor site after free gingival graft harvesting and covered by periodontal pack
Topical application of 0.2% hyaluronic acid gel
Topical application of 0.2% hyaluronic acid gel will be placed immediately in palatal donor site after free gingival graft harvesting
Platelet Rich Fibrin
Palatal donor site will receive a platelet rich fibrin and then will be sutured by criss cross suture then covered by periodontal pack.
Platelet rich fibrin
Placement of Platelet rich fibrin in the palatal donor sie after free gingival graft harvesting and suturing by criss cross sutured then covered by periodontal pack.
Interventions
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Topical application of 0.2% hyaluronic acid gel
Topical application of 0.2% hyaluronic acid gel will be placed immediately in palatal donor site after free gingival graft harvesting
Platelet rich fibrin
Placement of Platelet rich fibrin in the palatal donor sie after free gingival graft harvesting and suturing by criss cross sutured then covered by periodontal pack.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age at least 18 years.
* Not having any systemic disease that could compromise wound healing
* No previous periodontal surgery on the experimental sites.
Exclusion Criteria
* Loss of maxillary premolars and molars.
* Pregnancy or lactation
* Smoking
18 Years
65 Years
ALL
Yes
Sponsors
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Cairo University
OTHER
mostafa soliman
OTHER
Responsible Party
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mostafa soliman
Principle Investigator
Principal Investigators
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Mona M Shoeib, P.H.D
Role: STUDY_DIRECTOR
Cairo University
Locations
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Faculty of Dental Medicine - Cairo University -
Giza, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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CEBD-CU-2018-09-17
Identifier Type: -
Identifier Source: org_study_id
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