Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-09-02

Study Completion Date

2026-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation. We are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing.

Aim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

How COVID-19 Effects to Muscle Mass Change ın ICU?

NCT05008562

SARS-CoV-2 Acute Respiratory Disease Sarcopenia ICU Acquired Weakness +1 more

COMPLETED

Nutritional Status, Muscle Wasting and Fraility in Intensive Care Patients

NCT04709198

Critical Illness Nutritional Disorder

COMPLETED

Metabolic and Muscle Profile in ICU Survivors

NCT07329530

Critical Illness Major Abdominal Surgeries

RECRUITING NA

Abdominal Adiposity and Muscle Mitochondrial Functions

NCT00446745

Mitochondrial Respiratory Chain Deficiencies

COMPLETED

Diagnosing Intensive Care Unit (ICU) Acquired Weakness

NCT04166630

ICU Acquired Weakness

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Metabolomics Critical Care Critical Illness Critical Illness Myopathy Critical Illness Polyneuropathy Intensive Care (ICU) Myopathy Muscle Weakness

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Intensive Care Patients

Postoperative high-risk patients who have been admitted to intensive care after surgery

No interventions assigned to this group

Operative Control patients

Elective operative patients where control blood samples and muscle ultrasound will be measured.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* invasive mechanically ventilated critically ill patient with expected intensive care unit stay \> 3 days
* postoperative patient
* ≥ 18 years old
* American Society of Anesthesiology (ASA) classification ≥ III