Normative Values for Peripheral Muscle Strength in Critical Patients and Healthy Individuals
NCT ID: NCT06296381
Last Updated: 2025-09-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
180 participants
OBSERVATIONAL
2024-03-01
2028-12-30
Brief Summary
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Detailed Description
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In the case of assessing healthy participants, an evaluation of the musculoskeletal system will be conducted to measure muscle strength (handgrip dynamometry and peripheral hand held muscle dynamometry). Regarding critical patients, if the participant meets the criteria, the evaluation protocol will be carried out, which includes peripheral muscle strength assessment (Medical Research Council scale, Hand Dynamometer, and the Hand-Held Dynamometer) and the patient's mobility status (ICU Mobility Scale).
Daily screening will take place in the ICU, with eligibility assessed during the screening process. If eligible, secondary data related to the critical condition will be extracted from the participant's medical records, including anthropometric data, sociodemographic information, neurological and cardiovascular assessments, current medications, and laboratory test results. The participant's hemodynamic and respiratory stability will be monitored using a multiparameter monitor, recording data such as blood pressure, heart rate, peripheral saturation, and respiratory rate. A cardiorespiratory and clinical safety checklist will also be completed prior to conducting tests for all patients, regardless of whether they are using mechanical ventilation. The instruments used for assessment the muscle strength are the Digital Hand Dynamometer (Saehan Corporation®, DHD-1) and the Hand Held Dynamometer (HOGGAN SCIENTIFIC LLC, microFET2).
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients in the ICU
The ICU sample will comprised patients of both sexes, aged between 18 and 90 years old, able to do volitional tests and without barriers to the assessment of peripheral muscle strength.
No interventions assigned to this group
Healthy Participants
The healthy sample will comprised volunteers of both sexes, aged between 18 and 90 years old, able to do volitional tests and without barriers to the assessment of peripheral muscle strength.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Patients and volunteers aged between 18 and 90 years old (youth/adults/elderly).
* Patients admitted to the ICU.
* No recent muscle injuries of both limbs for a past 6-months.
Exclusion Criteria
Healthy individuals
* Unable to follow command completely
* Severe osteoporosis or neuromuscular disease leading to decreased muscle strength
* Presence of opened or infectious wound
* Presence of pain in evaluating muscle groups
Patients in ICU
* Unable to follow command completely
* Acute stroke
* Hip fracture, unstable cervical spine or pathological fracture
* Recent surgery involving the upper airways, chest, abdomen, or limbs
* Presence of opened or infectious wound
* Presence of pain in evaluating muscle groups
18 Years
90 Years
ALL
No
Sponsors
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Universidade Federal de Pernambuco
OTHER
Conselho Nacional de Desenvolvimento Científico e Tecnológico
OTHER_GOV
University of Pernambuco
OTHER
Responsible Party
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Shirley Lima Campos
Associate Professor
Principal Investigators
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Pedro Vinicius Porfirio
Role: PRINCIPAL_INVESTIGATOR
University of Pernambuco
Shirley Campos
Role: STUDY_CHAIR
University of Pernambuco
Locations
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Complexo Hospitalar Unimed Recife - CHUR
Recife, Brazil, Brazil
Federal University of Pernambuco (UFPE)
Recife, Pernambuco, Brazil
Hospital Otávio de Freitas
Recife, Pernambuco, Brazil
Hospital Nossa Senhora das Graças
Recife, Pernambuco, Brazil
Countries
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Central Contacts
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Facility Contacts
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References
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Lumbroso L, Doz F, Urbieta M, Levy C, Bours D, Asselain B, Vedrenne J, Zucker JM, Desjardins L. Chemothermotherapy in the management of retinoblastoma. Ophthalmology. 2002 Jun;109(6):1130-6. doi: 10.1016/s0161-6420(02)01053-9.
Teale JD. The diagnostic application of serum growth hormone, insulin-like growth factor (IGF), and IGF binding protein measurements. J Int Fed Clin Chem. 1995 Nov;6(5):164-8.
Saraiva MD, Venys AL, Abdalla FLP, Fernandes MS, Pisoli PH, Sousa DMDRV, Bianconi BL, Henrique EA, Garcia VSS, Maia LHM, Suzuki GS, Serrano PG, Hiratsuka M, Szlejf C, Jacob-Filho W, Paschoal SMP. AMPI-AB validity and reliability: a multidimensional tool in resource-limited primary care settings. BMC Geriatr. 2020 Mar 30;20(1):124. doi: 10.1186/s12877-020-01508-9.
Samosawala NR, Vaishali K, Kalyana BC. Measurement of muscle strength with handheld dynamometer in Intensive Care Unit. Indian J Crit Care Med. 2016 Jan;20(1):21-6. doi: 10.4103/0972-5229.173683.
Stark T, Walker B, Phillips JK, Fejer R, Beck R. Hand-held dynamometry correlation with the gold standard isokinetic dynamometry: a systematic review. PM R. 2011 May;3(5):472-9. doi: 10.1016/j.pmrj.2010.10.025.
Nunez-Cortes R, Cruz BDP, Gallardo-Gomez D, Calatayud J, Cruz-Montecinos C, Lopez-Gil JF, Lopez-Bueno R. Handgrip strength measurement protocols for all-cause and cause-specific mortality outcomes in more than 3 million participants: A systematic review and meta-regression analysis. Clin Nutr. 2022 Nov;41(11):2473-2489. doi: 10.1016/j.clnu.2022.09.006. Epub 2022 Sep 16.
Other Identifiers
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6.131.540
Identifier Type: -
Identifier Source: org_study_id
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