Evaluation and Training of Muscle Fitness in Pre-frail Individuals
NCT ID: NCT02122653
Last Updated: 2014-04-24
Study Results
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Basic Information
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COMPLETED
NA
42 participants
INTERVENTIONAL
2012-08-31
2013-07-31
Brief Summary
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The muscle weakness and fatigue can be categorized into peripheral or central causes. The central fatigue and voluntary activation failure originate from the decrease in motivation or the reduction of the conduction within corticospinal tracts. Long term activation failure and central fatigue will cause disuse of muscle and result in peripheral weakness and peripheral fatigue. Studies found the selective type II fiber atrophy in aged people and this finding was different from the type I atrophy in conventional immobilization models. It is possible that the activation failure leads to the recruitment failure of high threshold type II fibers at the pre-frail stage. Quantifying the weighting of central versus peripheral factors contributing to the exercise limitation in pre-frail people is important.
Most of the conventional strength and endurance training programs are based on the researches of young groups. These programs are not able to prevent people become frail. It is possibly that, due to the limitation of central fatigue, the pre-frail individuals stop exercise before the effective intensity being achieved. Almost no training program has been design for enhancing the voluntary activation level and relief the central fatigue. Seeking an appropriate training program to enhance central activation at the pre-frail stage is very important for preventing people become frail.
Previous studies have shown that increasing afferent input by peripheral electrical stimulation (ES) at sensory threshold enhanced the plasticity of contralateral primary sensory cortex, the excitability of corticospinal tracts, and the functional performance in young adults. ES, which is easy to quantify the dose of afferent input, is a feasible method to be used in training. Combining afferent input with strength training might be able to overcome the central activation failure and help recruit high threshold motor unit in pre-frail individuals.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Older WT
Older people with weight training
Weight training
Participants will perform 4 weeks of Weight training for lower extremities.
Older WT and ES
Older people with weight training combined electrical stimulation.
Weight training
Participants will perform 4 weeks of Weight training for lower extremities.
Electronic muscle stimulator
Participants will perform 4 weeks of electrical stimulation for Quadriceps muscle belly.
Young control group
Young people with control group
No interventions assigned to this group
Interventions
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Weight training
Participants will perform 4 weeks of Weight training for lower extremities.
Electronic muscle stimulator
Participants will perform 4 weeks of electrical stimulation for Quadriceps muscle belly.
Eligibility Criteria
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Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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Chang Gung University
OTHER
Responsible Party
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Ya-Ju Chang
Professor
Locations
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Chang Gung University
Taoyuan District, , Taiwan
Countries
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Other Identifiers
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10044
Identifier Type: -
Identifier Source: org_study_id
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