Quantifying the Trainability of Peripheral Nerve Function in Young and Older Adults.

NCT ID: NCT06614556

Last Updated: 2024-09-26

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 59 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-09-20
• Study Completion Date: 2023-07-18

Brief Summary

The purpose of this project is to identify the effects of hand grip resistance training on nerve speed of the hand muscles and to quantify whether age plays a role in those effects. Two groups (young and older adults) underwent a 4-week resistance training intervention with nerve conduction velocity measured before and after. There were also two control groups (young and older adults) who performed the testing 4 weeks apart, but did not engage in the intervention.

Detailed Description

Studies have shown that nerve speed slows with advancing age. As a result, slower nerves may result in slower movement speed and can alter response time. The investigators propose that a resistance training intervention may elicit positive adaptations to the nerves. The purpose of this project is to identify the effects of hand grip resistance training on nerve speed of the hand muscles and to quantify whether age plays a role in those effects. Two groups (young and older adults) underwent a 4-week, at-home, resistance training intervention with nerve conduction velocity (m/s) measured before and after. There were also two control groups (young and older adults) who performed the testing 4 weeks apart, but did not engage in the intervention. Other outcome measures included nerve size, via ultrasound, maximal handgrip strength, and hand dexterity.

Conditions

Nerve Degeneration; Healthy Aging

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: FACTORIAL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

Young Training Group

Ages 18-35. Performed 4 weeks of an at-home, hand grip resistance training intervention.

Group Type: EXPERIMENTAL

Resistance Training

Intervention Type: OTHER

Participants in the training groups performed bilateral hand grip resistance training three times per week for four weeks using a specialized hand-grip kit provided to them. Participants were provided with pictures and instructions for each exercise upon completion of the initial testing (PRE) session. They were asked to perform 12 training sessions (approximately 30-45 mins) over the 4 weeks according to their schedule. Each participant was asked to keep a training log to assist with accountability. Those assigned to the control groups were asked to maintain their normal daily activities throughout the four weeks.

Young Control Group

Ages 18-35. Did not perform the training intervention

Group Type: NO_INTERVENTION

No interventions assigned to this group

Older Training Group

Ages 60+. Performed 4 weeks of an at-home, hand grip resistance training intervention.

Group Type: EXPERIMENTAL

Resistance Training

Intervention Type: OTHER

Participants in the training groups performed bilateral hand grip resistance training three times per week for four weeks using a specialized hand-grip kit provided to them. Participants were provided with pictures and instructions for each exercise upon completion of the initial testing (PRE) session. They were asked to perform 12 training sessions (approximately 30-45 mins) over the 4 weeks according to their schedule. Each participant was asked to keep a training log to assist with accountability. Those assigned to the control groups were asked to maintain their normal daily activities throughout the four weeks.

Older Control Group

Ages 60+. Did not perform the training intervention

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Resistance Training

Participants in the training groups performed bilateral hand grip resistance training three times per week for four weeks using a specialized hand-grip kit provided to them. Participants were provided with pictures and instructions for each exercise upon completion of the initial testing (PRE) session. They were asked to perform 12 training sessions (approximately 30-45 mins) over the 4 weeks according to their schedule. Each participant was asked to keep a training log to assist with accountability. Those assigned to the control groups were asked to maintain their normal daily activities throughout the four weeks.

Intervention Type: OTHER

Other Intervention Names

Strength Training; Exercise

Eligibility Criteria

Inclusion Criteria

• Apparently healthy adults 18 - 100 years old.

Exclusion Criteria

• If you have been notified by a physician to refrain from exercise due to cardiovascular issues.
• Known orthopedic or neuromuscular limitations or illness of the upper extremities.
• Known neuromuscular disorders.
• Individuals that are experiencing a fever (> 100.4° F) or have identified as symptomatic on the COVID-19 screening questionnaire may not participate at this time.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

American College of Sports Medicine - Central States Chapter

UNKNOWN

Sponsor Role: collaborator

Oklahoma State University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Jason M DeFreitas, PhD

Role: PRINCIPAL_INVESTIGATOR

Oklahoma State University

Locations

Applied Neuromuscular Physiology Laboratory

Stillwater, Oklahoma, United States

Countries

United States

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

IRB-22-270

Identifier Type: -

Identifier Source: org_study_id