Impact of Aerobic Exercise Training on Sympathetic Vasoconstriction and Vascular Function in Essential Hypertension

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-02-19

Study Completion Date

2022-11-01

Brief Summary

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Sympathetic nervous activity plays an important role in the development of hypertension and studies have shown that the pannexin-1 channel is involved in the signalling of the sympathetic activity to the vascular bed. The main project aim is to investigate the effects of 10 weeks of high intensity training on the effect of the sympathetic nervous activity on vascular function in individuals with essential hypertension. A secondary aim is to assess the role of essential hypertension and physical activity on vascular endothelial function,

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Detailed Description

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Conditions

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Hypertension,Essential

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized double blinded case-control interventional study

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Hypertensive

Men and women in age-group 35-65 years Resting blood pressure of \>140/90 mmHg non or only anti-hypertensive medication

Group Type EXPERIMENTAL

Training

Intervention Type OTHER

10 weeks of high intensity exercise training. 2-3 trainings per week of approx. 40 min.

Control

Men and women in age-group 35-65 years Resting blood pressure of \<140/90 mmHg no medication

Group Type ACTIVE_COMPARATOR

Training

Intervention Type OTHER

10 weeks of high intensity exercise training. 2-3 trainings per week of approx. 40 min.

Interventions

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Training

10 weeks of high intensity exercise training. 2-3 trainings per week of approx. 40 min.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Sedentary men and women age 35 - 65 years
* Resting blood pressure \>140/90 mmHg or Resting blood pressure \<140/90 mmHg
* Essential hypertension
* Non or exclusively antihypertensive medication