Effect of NO Precursors on Physiological Responses to Exercise

NCT ID: NCT02850367

Last Updated: 2025-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

63 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-05-09

Study Completion Date

2021-09-30

Brief Summary

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NO is an ubiquitous molecule contributing to many physiological functions such as vasodilation, immune and oxidative stress responses. NO production can be supplemented either by providing substrate to the NO-synthase (L-Arginine and L-Citruline) or by providing nitrate which can lead to NO. In the present project the investigators evaluate the effect of various acute and chronic oral NO precursors supplementation on exercise performance and responses in healthy young and older subjects.

Detailed Description

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Conditions

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Physiology

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Acute intake

Evaluation after acute intake of the food supplement.

Group Type ACTIVE_COMPARATOR

Nitrate

Intervention Type DIETARY_SUPPLEMENT

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

Nitrate and L-Arginine

Intervention Type DIETARY_SUPPLEMENT

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

Nitrate and L-Citrulline

Intervention Type DIETARY_SUPPLEMENT

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

Placebo

Intervention Type DIETARY_SUPPLEMENT

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with a placebo.

Evaluation of post-ischemic vascular reactivity

Intervention Type BIOLOGICAL

After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS.

Neuromuscular evaluations

Intervention Type BIOLOGICAL

After the intake of the supplement. Measure the stretching force in the ankle (N)

Chronic intake

Evaluation before and after chronic intake of the food supplement.

Group Type ACTIVE_COMPARATOR

Nitrate and L-Citrulline

Intervention Type DIETARY_SUPPLEMENT

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

Placebo

Intervention Type DIETARY_SUPPLEMENT

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with a placebo.

Evaluation of post-ischemic vascular reactivity

Intervention Type BIOLOGICAL

After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS.

Neuromuscular evaluations

Intervention Type BIOLOGICAL

After the intake of the supplement. Measure the stretching force in the ankle (N)

Interventions

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Nitrate

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

Intervention Type DIETARY_SUPPLEMENT

Nitrate and L-Arginine

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

Intervention Type DIETARY_SUPPLEMENT

Nitrate and L-Citrulline

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.

Intervention Type DIETARY_SUPPLEMENT

Placebo

Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with a placebo.

Intervention Type DIETARY_SUPPLEMENT

Evaluation of post-ischemic vascular reactivity

After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS.

Intervention Type BIOLOGICAL

Neuromuscular evaluations

After the intake of the supplement. Measure the stretching force in the ankle (N)

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Sedentary subjects
* No cardiovascular, respiratory, metabolic and neurological disorders

Exclusion Criteria

* Body mass index \> 28 kg.m-2
* Smoker
* Alcool intake \> 10g/day
* Psychiatric diseases
* Subjects under treatment able to interfere with their cardiovascular, metabolic and neurological status
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Stéphane Doutreleau, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Grenoble

Locations

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Grenoble University Hospital

Grenoble, Auvergne-Rhône-Alpes, France

Site Status

Countries

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France

References

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LE Roux-Mallouf T, Vallejo A, Pelen F, Halimaoui I, Doutreleau S, Verges S. Synergetic Effect of NO Precursor Supplementation and Exercise Training. Med Sci Sports Exerc. 2020 Nov;52(11):2437-2447. doi: 10.1249/MSS.0000000000002387.

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Other Identifiers

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38RC14.430

Identifier Type: -

Identifier Source: org_study_id