Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients
NCT ID: NCT06169241
Last Updated: 2025-05-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
EARLY_PHASE1
50 participants
INTERVENTIONAL
2023-11-01
2025-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
QUADRUPLE
Study Groups
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Placebo
The placebo group will be administered as a colored and flavored isocaloric supplement composed of maltodextrin.
Placebo
The placebo will be administered as a colored and flavored isocaloric supplement composed of maltodextrin.
Beetroot extract
Beetroot extract powder supplementation with 400mg of nitrate per dose in the amount of 10g per day orally will be used in the group.
Beetroot extract
Beetroot extract powder supplementation with 400mg of nitrate per dose in the amount of 10g per day orally will be used in the group.
Interventions
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Beetroot extract
Beetroot extract powder supplementation with 400mg of nitrate per dose in the amount of 10g per day orally will be used in the group.
Placebo
The placebo will be administered as a colored and flavored isocaloric supplement composed of maltodextrin.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* heart failure
* use of medications with nitrate in their formula
* patients undergoing renal denervation
18 Years
75 Years
ALL
No
Sponsors
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National Institute of Cardiology, Laranjeiras, Brazil
OTHER_GOV
Responsible Party
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Eduardo Tibirica, MD, PhD
Senior Researcher
Locations
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National Institute of Cardiology
Rio de Janeiro, , Brazil
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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70847523.9.0000.5272
Identifier Type: -
Identifier Source: org_study_id
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