Classical Trigeminal Neuralgia and Sodium Channel Mutations

NCT ID: NCT03656497

Last Updated: 2018-09-05

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 33 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-11-01
• Study Completion Date: 2018-08-01

Brief Summary

The most common cause of trigeminal neuralgia is considered to be a neurovascular contact. However, this etiological factor only seem to be present in half of the patient group. Thus the etiology of the other half is unknown.

Gain-of function genetic mutations in voltage gated sodium channels have been hypothesized as playing a role in the etiology of trigeminal neuralgia but it has yet to be confirmed. In recent years gain-of-function mutations have been identified as a causative factor in other pain-diseases presenting with trigeminal neuralgia phenotypic similarities.

Detailed Description

The aim of this study was to indentify VGSC gene mutations, specifically SCN9A, SCN10A and SCN11A genes, in a group of well characterized trigeminal neuralgia patients.

Setting: The study will be conducted at The Danish Headache Center, Rigshospitalet - Glostrup, Denmark (inclusion of patients and written Informed Consent, patient interview, phenotyping/diagnosis, neurological examination, blood sample.

Departments of Neurology and Clinical Genomics of the Maastricht University Medical Center, Maastricht, the Netherlands: Targeted NG Sanger Sequencing

Conditions

Trigeminal Neuralgia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: OTHER

Interventions

Observational

No intervention is conducted as the study aim is to explore the link between pheno- and genetype of trigeminal neuralgia

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. Patients must be able to give Signed Informed Consent prior to study entry

2. Patients fulfilling of the ICHD-3 beta diagnostic criteria for classical TN.1

3. Age 18 years or older.

4. Age at debut < 42 years and/or confirmed first-line relative with TN.

5. Respond to sodium channel blockers with a 50% reduction of pain intensity evaluated by both the patient and the examining physician using the visual analog scale (VAS).

Exclusion Criteria

1. Psychiatric or mental illness of physical condition that might interfere with the ability of the patients to fill in the Informed Consent and questionnaires.

2. History of herpes zoster in the distribution of the trigeminal nerve ipsilateral to pain, multiple sclerosis or a space-occupying lesion.

3. History indicative of painful posttraumatic trigeminal neuropathy such as previous trauma, surgery or radiation to the trigeminal nerve ipsilateral to pain.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Maastricht University Medical Center

OTHER

Sponsor Role: collaborator

Danish Headache Center

OTHER

Sponsor Role: lead

Responsible Party

Tone Heinskou

MD, PhD student

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Lars Bendtsen, ass. prof.

Role: STUDY_CHAIR

Danish Headache Center

Other Identifiers

H-15010165

Identifier Type: -

Identifier Source: org_study_id