Central and Peripheral Adiposity and Iron Absorption

NCT ID: NCT03642223

Last Updated: 2019-03-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

121 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-10

Study Completion Date

2018-10-18

Brief Summary

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Adiposity is a state of sub-clinical inflammation, thus hepcidin is increased in adiposity, often leading to iron deficiency in this population group. Central adiposity is generally considered having a greater negative effect on health compared to peripheral adiposity. Whether this can be also seen in hepcidin and thereby in iron absorption is uncertain.

Detailed Description

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Conditions

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Adiposity Iron-deficiency

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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normal-weight

Group Type ACTIVE_COMPARATOR

Stable iron isotopes

Intervention Type OTHER

Participants have to consume a test meal containing stable iron isotopes in order to determine iron absorption

peripheral adiposity

Group Type EXPERIMENTAL

Stable iron isotopes

Intervention Type OTHER

Participants have to consume a test meal containing stable iron isotopes in order to determine iron absorption

central adiposity

Group Type EXPERIMENTAL

Stable iron isotopes

Intervention Type OTHER

Participants have to consume a test meal containing stable iron isotopes in order to determine iron absorption

Interventions

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Stable iron isotopes

Participants have to consume a test meal containing stable iron isotopes in order to determine iron absorption

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* either normal-weight (BMI 18-25kg/m2) or overweight/obese (BMI 28-50kg/m2) with either central or peripheral fat deposits based on DEXA

Exclusion Criteria

* Iron Supplement or antibiotic intake within 2 weeks before study start
* diagnosed chronic disease or gastrointestinal disorders
* regular use of medication (except contraceptives)
* pregnancy
* lactation
* smoking
* blood donation or surgery within the last 4 months.
Minimum Eligible Age

20 Years

Maximum Eligible Age

55 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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American University of Beirut Medical Center

OTHER

Sponsor Role collaborator

Swiss Federal Institute of Technology

OTHER

Sponsor Role lead

Responsible Party

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Prof. Michael B. Zimmermann

Prof. Dr. med.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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American University of Beirut

Beirut, , Lebanon

Site Status

Countries

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Lebanon

References

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El-Helou N, El-Mallah C, Wehbe N, Bissani N, Stoffel N, Herter-Aeberli I, Zimmermann M, Obeid O. A test to measure oral iron absorption and glucose tolerance simultaneously in 18 to 55 year old premenopausal women. Clin Nutr ESPEN. 2021 Dec;46:325-329. doi: 10.1016/j.clnesp.2021.09.737. Epub 2021 Sep 29.

Reference Type DERIVED
PMID: 34857214 (View on PubMed)

Other Identifiers

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FLAB

Identifier Type: -

Identifier Source: org_study_id

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