Obesity, Physical Inactivity or Dietary Fat ?

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-03-31

Study Completion Date

2011-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Obesity is the consequence of a chronic disequilibrium of fat balance. Genetic factors determine predisposition to obesity, but the most often mentioned idea is that environmental factors, such as a high-fat diet and a sedentary lifestyle, join to favour weight gain and explain the increased prevalence of obesity in our westernized societies. Since lipogenesis is negligible in humans, obesity represents the consequence of altered fat partitioning between oxidation and storage, likely due to a preferential directing of dietary fat towards adipose tissue and away from muscle. Interventions that favour partitioning of dietary fat towards muscle for oxidation might thus protect against weight gain. Exercise may be one kind of such intervention but the scant data on dietary fat metabolism does not allow clear conclusions, in particular in obese subjects. One question concerns the impact of the type of fat eaten: the effects of physical inactivity may vary according to the length and saturation degree of the fatty acids. We hypothesize that 1) physical activity of moderate intensity, independently of its effect on energy balance, will favor a preferential trafficking towards adipose tissue, will modify the expression of genes implicated in fat oxidation and storage and partly correct the abnormalities observed in obese subjects, 2) effects of physical activity vary according to the saturation degree of fat. Twelve obese subjects, aged 18 to 55, will undergo tests before and after 2 months of training at current recommendations to ascertain dietary fat partitioning using stable isotopes and to determine changes in gene expression with muscle and adipose tissue microbiopsies.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Endothelial Dysfunction in Obese Children

NCT01461226

Obesity Atherosclerosis

COMPLETED NA

Body Composition and Lipid Metabolism at Rest and During Exercise: A Cross-Sectional Analysis.

NCT03029364

Lipid Metabolism Substrate Metabolism Exercise

COMPLETED

Body Fat Distribution and Fat Metabolism

NCT00475774

Obesity Metabolic Disease

COMPLETED NA

Effect of Nutritional Intervention and Olive Oil in Severe Obesity

NCT02463435

Severe Obesity

COMPLETED NA

Physical Activity Level and Hormonal Status on Energy Metabolism and Nutritional Responses

NCT05944653

Women Metabolism

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Obesity

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Physical training

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Men between 18 and 55
* IMC \>25 and \<30 kg/m2 and waist circumference \>102 cm
* Familial antecedents of obesity
* Physical inactivity (PAL\<1.5, according to MOSPA-questionnaire and accelerometry)
* Acceptation of physical training and body weight control during the study

Exclusion Criteria

* Any drug interfering with energetic or lipid metabolism
* Any contradiction to moderate physical training
* Diabetes or arterial hypertension treatment
* Any other pathology (cardiovascular, psychiatric, renal or hepatic disease, viral hepatitis or VIH)
* Consumption of more than 40 g alcohol per day
* Recent voluntary or involuntary weight modification (3kg the next three months)
* A recent trip outside France before and during stable isotope measures.

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No