The Dietary Education Trial in Carbohydrate Counting (DIET-CARB Study in Type 1 Diabetes

NCT ID: NCT03623113

Last Updated: 2024-01-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

63 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-09-28

Study Completion Date

2022-08-17

Brief Summary

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The study is designed to evaluate two different dietitian-led self-management approaches in carbohydrate counting compared to routine dietary care (control) on glycaemic control in adult patients with type 1 diabetes:

1. The basic carbohydrate counting concept aims at improving carbohydrate counting accuracy and day-to-day consistency of carbohydrate intake (the BCC intervention)
2. The advanced carbohydrate counting concept aims at improving prandial insulin dose accuracy using an automated bolus calculator (the ABC-ACC intervention)

The main hypothesis is that structured training and education in either the BCC concept or the ABC-ACC concept will reduce HbA1c or the average glucose variability more than routine dietary education.

Detailed Description

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The current study is a randomized controlled trial with a parallel-group design. A total of 231 patients will be enrolled in the trial. Participants will be randomized to one of three arms: 1) Basic carbohydrate counting (BCC), 2) Advanced carbohydrate counting with an automated bolus calculator (ABC-ACC), or 3) Standard dietary care.

The primary objective is to evaluate the six months effects of education in the BCC concept and the ABC-ACC concept compared to standard dietary care on glycaemic control as assessed by HbA1c or MAGE (mean amplitude of glycaemic excursions).

Conditions

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Type1diabetes Type1 Diabetes Mellitus Glucose Metabolism Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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BCC intervention

The BCC program consists of three group sessions and is delivered by two trained dietitians. In addition to the BCC program, the participants receive regular medical care in the diabetes clinic

Group Type EXPERIMENTAL

BCC intervention

Intervention Type BEHAVIORAL

Structured training and education i basic carbohydrate counting principles

ABC-ACC intervention

The ABC-ACC program consists of one group session and two individual follow-up sessions and is delivered by trained dietitians with supervision by a medical doctor. In addition to the ABC-ACC program, the participants receive regular medical care in the diabetes clinic

Group Type EXPERIMENTAL

ABC-ACC intervention

Intervention Type BEHAVIORAL

Structured training and education i advanced carbohydrate counting principles including the use of a automated bolus calculator carbohydrate

Standard dietary education

The routine outpatient dietary care consists of three individual consultations delivered by a trained dietitian. The individual guidance is based on the overall treatment goal(s), the defined personal dietary goals for behavioral change which will be in accordance with the patient's needs and preferences. In addition to the dietary counselling, the participants receive regular medical care in the diabetes clinic

Group Type ACTIVE_COMPARATOR

Standard dietary education

Intervention Type BEHAVIORAL

Personalized individual dietary counselling based on overall meal planning, dietary guidelines and the patient's need and preferences

Interventions

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BCC intervention

Structured training and education i basic carbohydrate counting principles

Intervention Type BEHAVIORAL

ABC-ACC intervention

Structured training and education i advanced carbohydrate counting principles including the use of a automated bolus calculator carbohydrate

Intervention Type BEHAVIORAL

Standard dietary education

Personalized individual dietary counselling based on overall meal planning, dietary guidelines and the patient's need and preferences

Intervention Type BEHAVIORAL

Other Intervention Names

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Basic carbohydrate counting Advanced carbohydrate counting with a bolus calculator Routine dietary care

Eligibility Criteria

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Inclusion Criteria

* Type 1 diabetes
* Diabetes duration; \>12 months
* HbA1c of 53-97 mmol/mol
* Multiple daily insulin injection therapy
* Provided voluntary written informed consent

Exclusion Criteria

* Practicing carbohydrate counting, as judged by the investigator
* Participated in a BCC group program within the last two years
* Use of insulin pump, or plans of having an insulin pump within the study period
* Fixed dose of rapid acting insulin therapy for meals
* Split-mixed insulin therapy
* Use of open CGM
* Use of Freestyle Libre
* Use of an automated bolus calculator
* Gastroparesis
* Pregnancy or breastfeeding, or plans of pregnancy within the study period
* Low daily intake of carbohydrates (defined as below 25 E% or 100 g/day), as judged by the investigator
* Uncontrolled medical issues, as judged by the investigator or a medical expert
* Concomitant participation in other clinical studies
* Unable to understand the informed consent and the study procedures
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Copenhagen

OTHER

Sponsor Role collaborator

Steno Diabetes Center Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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Bettina Ewers

Head of Nutrition

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bettina Ewers, MSc

Role: PRINCIPAL_INVESTIGATOR

Steno Diabetes Center Copenhagen

Locations

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Steno Diabetes Center Copenhagen

Gentofte Municipality, , Denmark

Site Status

Countries

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Denmark

References

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Ewers B, Vilsboll T, Andersen HU, Bruun JM. The dietary education trial in carbohydrate counting (DIET-CARB Study): study protocol for a randomised, parallel, open-label, intervention study comparing different approaches to dietary self-management in patients with type 1 diabetes. BMJ Open. 2019 Sep 3;9(9):e029859. doi: 10.1136/bmjopen-2019-029859.

Reference Type DERIVED
PMID: 31481560 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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H-18014897

Identifier Type: -

Identifier Source: org_study_id

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