Influence of Mango Intake of Skin Health in Postmenopausal Women

NCT ID: NCT03590756

Last Updated: 2019-10-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-07-17

Study Completion Date

2019-05-31

Brief Summary

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This study aims to investigate the effects on 16 weeks of mango intake on skin health in postmenopausal women. Half of the participants will receive 85g portions of mangoes while the other half receive 250g portions of mangos. Participants will be instructed to consume the specific portion 4 times a week, for a total duration of 16 weeks.

Detailed Description

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Mangoes are rich in carotenoids, flavonoids, vitamins and other active phytochemicals such as resistant starches. Although a role of mangoes in skin health has long been advocated in traditional medicine, little scientific research has been conducted.

We hypothesize that 85g (0.5 cups) of mango intake for 16 weeks will have minimal impact on skin health, while 250g (1.5 cups) of mango intake will produce significant benefits.

Conditions

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Wrinkle Skin Red

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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High mango group

250g (1.5 cup) of mango intake per day, 4 days a week for 16 weeks

Group Type EXPERIMENTAL

16 weeks mango intake

Intervention Type OTHER

Participants will be provided fresh frozen Ataulfo mangoes.

Low mango group

85g (0.5 cup) of mango intake per day, 4 days a week for 16 weeks

Group Type OTHER

16 weeks mango intake

Intervention Type OTHER

Participants will be provided fresh frozen Ataulfo mangoes.

Interventions

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16 weeks mango intake

Participants will be provided fresh frozen Ataulfo mangoes.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Postmenopausal
* Fitzpatrick skin type I and II
* BMI 18.5 - 35.0 kg/m2
* Normal blood levels in the comprehensive metabolic panel, or values slightly out of range as approved by the study physician

Exclusion Criteria

* Allergic to mangoes
* Fruit consumption of 2 or more cups per day
* Vegetable consumption of 3 or more cups per day for females
* Fruit juice consumption of more than 1 cup per day
* Self-reported malabsorption
* Currently taking regular prescription drugs i.e. statins, thyroid, anti-inflammatory drugs
* Had any medical or cosmetic procedures such as laser resurfacing or plastic surgery to the face within the last 6 months, including botulinum toxin, dermal fillers, collagen or other similar cosmetic procedure
* Autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos)
* Smoking (current smoker, smoked within the past year, former smokers with greater than a 20 pack-year history of smoking within the past 20 years.
* Indications of substance or alcohol abuse
* Unwillingness to discontinue high antioxidant supplements during washout and interventions
Minimum Eligible Age

50 Years

Maximum Eligible Age

70 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Mango Board

OTHER

Sponsor Role collaborator

University of California, Davis

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Ragle Human Nutrition Research Center

Davis, California, United States

Site Status

Countries

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United States

Other Identifiers

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1185928

Identifier Type: -

Identifier Source: org_study_id

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