12-Week Study on the Efficacy of Two Serums in Improving Skin Aging and Tone

NCT ID: NCT07156071

Last Updated: 2025-09-08

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 120 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-11-18
• Study Completion Date: 2024-03-22

Brief Summary

This study aims to evaluate the anti-aging and skin tone improvement effects of two facial serums over a 12-week period. It was conducted at a single research center with a 2-week washout period followed by full-face application of the test products for 12 weeks.

A total of at least 120 healthy Chinese female participants aged 18 to 45 were enrolled and divided into two treatment groups:Each group included both early aging (18-29 years) and mature aging (30-45 years) subgroups, with at least 30 participants in each subgroup.

Conditions

Facial Skin Aging and Dullness

Study Design

• Allocation Method: NA
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Serum 1 Group

Participants in this arm applied Serum 1 (Fla#897183 329) to the full face twice daily for 12 weeks. The group included both early aging (18-29 years) and mature aging (30-45 years) subgroups.

Group Type: EXPERIMENTAL

Serum 1

Intervention Type: OTHER

Applied topically on the full face in the morning and evening for 12 weeks during the treatment period. Used by participants in the Serum 1 group.

Serum 2 Group

Participants in this arm applied Serum 2 (Fla#b50198) to the full face twice daily for 12 weeks. The group included both early aging (18-29 years) and mature aging (30-45 years) subgroups.

Group Type: EXPERIMENTAL

Serum 2

Intervention Type: OTHER

Applied topically on the full face in the morning and evening for 12 weeks during the treatment period. Used by participants in the Serum 2 group.

Interventions

Serum 1

Applied topically on the full face in the morning and evening for 12 weeks during the treatment period. Used by participants in the Serum 1 group.

Intervention Type: OTHER

Serum 2

Applied topically on the full face in the morning and evening for 12 weeks during the treatment period. Used by participants in the Serum 2 group.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. Chinese female aged 18-45 years (evenly split among Early aging [18-29 years] and Mature aging [30-45 years]).

2. All skin types (dry, normal, oily, or mixed).

3. Currently experiencing lack of radiance, roughness, dullness, and fine lines or wrinkles on facial skin as self-claimed.

4. Early aging group (18-29 years): Must present with corresponding severity for the attributes evaluated by Dermatologist, including:

• Skin smoothness, radiance, dullness: grade between 2 and 6 (scale 0-9);
• Size of acne marks (PIH): size ≥ 2;
• Small folds on nasolabial zone: grade between 1 and 3 (Skin Aging Atlas, 0-6 scale, Page 56-57).

5. Mature aging group (30-45 years): Must present with corresponding severity for the attributes evaluated by Dermatologist, including:

• Skin smoothness, radiance, dullness: grade between 4 and 6 (scale 0-9);
• Small folds on nasolabial zone: grade between 1 and 4 (Skin Aging Atlas, 0-6 scale, Page 56-57);
• Forehead wrinkles: grade ≥ 2 (Skin Aging Atlas, 0-8 scale, Page 32-33);
• Crow's feet wrinkles: grade ≥ 2 (Skin Aging Atlas, 0-6 scale, Page 40-41).

6. Regular user of serum and sunscreen products.

7. Did not participate in any clinical test or cosmetic product test on skin within the last 3 months.

8. No exclusion by dermatologist due to other medical or dermatological reasons.

9. In general good health at the time of the study.

10. Willing and able to participate as evidenced by signing of informed consent and photo release form.

11. Must be willing to comply with all study protocol requirements (including using only the skincare products provided during the study and not taking topical or oral treatments such as retinol, hormones, or antioxidant health supplements).

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

ChinaNorm

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Shanghai China-norm Quality Technical Service Co., Ltd., Shanghai, Shanghai 200072

Shanghai, , China

Countries

China

Other Identifiers

C23005059

Identifier Type: -

Identifier Source: org_study_id