The Effectiveness of Epidermal Growth Factor Serum in Improve Facial Skin Hydration, Elasticity, Pigmentation, and Wrinkles.

NCT ID: NCT05724589

Last Updated: 2025-07-31

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 28 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-01-30
• Study Completion Date: 2024-12-12

Brief Summary

EGF is a polypeptide that promotes cell differentiation and collagen production while decreasing melanin production. This study is designed to study its effectiveness in improving the texture and appearance of facial skin after daily topical application. We hypothesized that EGF would improve facial skin hydration, elasticity, pigmentation, and wrinkles.

Detailed Description

All patients gave written informed consent for epidermal growth factor serum application on the face. The pilot study enrolls thirty patients compared to pre and post-serum used to evaluate facial skin hydration, transepidermal water loss, elasticity, pigmentation, and wrinkles measured by corneometer, tewameter, cutometer, visioscan, and mexameter respectively on day 0, then 8, 12, and 16 weeks. The study evaluates subject satisfaction and side effects after serum application as secondary outcomes.

Conditions

Aging

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Epidermal Growth Factor Serum Application

Participants received Epidermal growth factor serum application on the face daily for two months compared to pre and post-results of skin quality.

Group Type: EXPERIMENTAL

Epidermal Growth Factor

Intervention Type: DRUG

Apply facial twice daily.

Interventions

Epidermal Growth Factor

Apply facial twice daily.

Intervention Type: DRUG

Other Intervention Names

Epidermal Growth Factor Serum

Eligibility Criteria

Inclusion Criteria

• Thai
• Mild to moderate facial skin condition, as measured by 1-2 points on the hyperpigmentation status scale or 2-3 points on the wrinkle severity grading scale.

Exclusion Criteria

• Use of lotions or skin care products containing ingredients such as vitamin A/C, hydroquinone, or anti-aging agents.
• Sunbathing
• Hypersensitivity to serum components
• Pregnancy and breast-feeding
• Active skin diseases such as eczema or atopic dermatitis at the application site

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Institute of Dermatology, Thailand

OTHER_GOV

Sponsor Role: lead

Responsible Party

Supawee Phanmamuang, MD

Resident of Dermatology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Chumsaeng Chumsaengsri

Role: PRINCIPAL_INVESTIGATOR

Institute of Dermatology

Locations

Institute of Dermatology

Bangkok, , Thailand

Countries

Thailand

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

008/2565

Identifier Type: -

Identifier Source: org_study_id