Safety and Effectiveness of Sculptra Aesthetic for Correction of Cheek Wrinkles

NCT ID: NCT04124692

Last Updated: 2023-11-18

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

149 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-12

Study Completion Date

2021-08-12

Brief Summary

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The study has been designed to evaluate the safety and effectiveness of Sculptra Aesthetic as a single regimen for correction of cheek wrinkles after changes in reconstitution and injection procedures compared to the approved label.

Detailed Description

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Conditions

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Cheek Wrinkles

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Control Group: No-treatment

Participants will receive no treatment during the study.

Group Type NO_INTERVENTION

No interventions assigned to this group

Treatment Group: Sculptra Aesthetic

Participants will be injected with Sculptra Aesthetic by Treating Investigator at Day 1 until optimal correction achieved (up to 4 total treatment sessions)

Group Type EXPERIMENTAL

Sculptra Aesthetic new dilution

Intervention Type DEVICE

Treatment of cheek wrinkles

Interventions

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Sculptra Aesthetic new dilution

Treatment of cheek wrinkles

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Intent to undergo correction of cheek wrinkles on both sides of the face and a Galderma Cheek Wrinkles Scale (GCWS) At Rest score of Moderate or Severe on EACH side of the face.

Exclusion Criteria

* Known/previous allergy or hypersensitivity to any of the Sculptra Aesthetic constituents.
* Previous tissue augmenting therapy, contouring or revitalization treatment in the face, except the lips, with any of the following fillers prior to Baseline visit:

1. Collagen, Hyaluronic Acid - 12 months
2. Calcium Hydroxyapatite (CaHa), Poly L- Lactic Acid (PLLA) or permanent (nonbiodegradable)- Prohibited
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Galderma R&D

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Galderma Research Site

Scottsdale, Arizona, United States

Site Status

Galderma Research Site

Encino, California, United States

Site Status

Galderma Research Site

Redondo Beach, California, United States

Site Status

Galderma Research Site

San Diego, California, United States

Site Status

Galderma Research Site

Washington D.C., District of Columbia, United States

Site Status

Galderma Research Site

Coral Gables, Florida, United States

Site Status

Galderma Research Site

Alpharetta, Georgia, United States

Site Status

Galderma Research Site

New Orleans, Louisiana, United States

Site Status

Galderma Research Site

Rockville, Maryland, United States

Site Status

Galderma Research Site

New York, New York, United States

Site Status

Galderma Research Site

New York, New York, United States

Site Status

Galderma Research Site

Dallas, Texas, United States

Site Status

Galderma Research Site

Spring, Texas, United States

Site Status

Countries

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United States

References

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Fabi SG, Le JHTD, Prygova I, Brasater D. Midface Projection Using Biostimulatory Poly- l -Lactic Acid Injectable Implant: A Subgroup Analysis of the Cheek Wrinkle Trial. Dermatol Surg. 2024 Dec 1;50(12):1137-1142. doi: 10.1097/DSS.0000000000004434. Epub 2024 Oct 17.

Reference Type DERIVED
PMID: 39453400 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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43USSA1812

Identifier Type: -

Identifier Source: org_study_id

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