The Effects of Almond on Facial Skin Collagen and Wrinkles
NCT ID: NCT06074276
Last Updated: 2024-06-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2023-10-04
2024-12-31
Brief Summary
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Detailed Description
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Almond consumption has been shown to significantly decrease wrinkle severity in two clinical studies conducted with postmenopausal women with Fitzpatrick skin type I and II. Almond intake has also been shown to increase resistance to erythema induced by ultraviolet exposure. The extracellular matrix contains proteins including collagen and elastin, which contributes to the integrity of the skin. Enzymatic and ultraviolet radiation induced degradation and a reduction in synthesis of collagen and elastin contribute to wrinkle formation. Furthermore, the process of menopause decreases the level of estrogen which affects the skin in several ways, including a decrease in skin collagen and hydration, and an increase in wrinkling.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Almonds
Consumption of almonds 5 times per week
Food: whole almonds
60 grams or (\~2 oz) will be consumed 5 times per week.
Control Snack
Consumption of protein and calorie matched non-nut-based food 5 times per week
Food: non-nut snack
Protein and calorie matched non-nut-based food will be consumed 5 times per week by mouth
Interventions
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Food: whole almonds
60 grams or (\~2 oz) will be consumed 5 times per week.
Food: non-nut snack
Protein and calorie matched non-nut-based food will be consumed 5 times per week by mouth
Eligibility Criteria
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Inclusion Criteria
* 50% of the subjects will be postmenopausal women determined as \>1-year loss of menstrual period
* 50% of the subjects will be premenopausal women
* BMI 18.5 - 35 kg/m2
* Individuals with a habitual diet that has been maintained for at least 6 months and to be maintained for the duration of the study
* Individuals must maintain their usual skincare products, defined as products that has been used for at least 1 month, for the duration of the study
Exclusion Criteria
* Those who are unwilling to discontinue oral collagen supplementation 1 month prior to the start of the study
* Individuals who are unwilling to discontinue vitamin E or nut containing supplements 2 weeks prior to and during the intervention.
* Individuals who are pregnant or breastfeeding
* Change in skincare products during the study
* Had a medical or cosmetic procedure such as laser resurfacing or plastic surgery to the face within the last 6 months (include botulinum toxin, dermal fillers, collagen, or other similar cosmetic procedure)
* Has an autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos)
* Those with a skin disease on their face that would affect the assessment of their skin based on the assessment of the investigator.
* Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years
35 Years
70 Years
FEMALE
Yes
Sponsors
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Integrative Skin Science and Research
INDUSTRY
Responsible Party
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Principal Investigators
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Raja Sivamani, MD MS AP
Role: PRINCIPAL_INVESTIGATOR
Integrative Skin Science and Research
Locations
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Integrative Skin Science and Research
Sacramento, California, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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i23-07_Almond_Collagen
Identifier Type: -
Identifier Source: org_study_id
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