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Pilot Investigation of a Multinutrient Supplement on Skin Aging and Aging Metabolites in Healthy Women

NCT ID: NCT00541931

Last Updated: 2017-11-20

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

37 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-10-31

Study Completion Date

2012-01-31

Brief Summary

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We are seeking healthy female volunteers to determine if multinutrient supplementation affects visible signs of skin aging as well as blood measurements of aging. We are seeking smokers and non-smokers.

Detailed Description

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Skin antioxidant levels as well as blood metabolites may change as the human body ages1,2. Although the chronological aging process is unstoppable, the physical signs of aging, particularly characteristics of the skin, may be delayed through a variety of medical interventions such as topical medications or resurfacing lasers. It is not currently known whether skin carotenoid antioxidant levels correlate with skin aging characteristics, although studies with other antioxidants suggest this may be true 3. In addition, while selected blood metabolites correlate with changes in age2, we do not know if this correlates with skin changes. Our current study focuses on whether differences in skin carotenoid levels and blood metabolite levels correlate with skin aging characteristics in age-matched subjects. Furthermore, we will explore whether three months consumption with a commercial multi-nutrient formulation (LifePak Nano) affects metabolic markers of aging, skin aging characteristics including skin elasticity and transepidermal water loss. We will also examine whether smokers respond differently from nonsmokers in the above parameters after supplementation.

Conditions

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Skin Diseases

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Nonsmoker

Nonsmokers Intervention: Dietary Supplement: LifePak Nano

Group Type OTHER

Dietary Supplement: LifePak Nano

Intervention Type DRUG

Daily use

Smoker

Smoker arm Intervention: Dietary Supplement: LifePak Nano

Group Type OTHER

Dietary Supplement: LifePak Nano

Intervention Type DRUG

Daily use

Interventions

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Dietary Supplement: LifePak Nano

Daily use

Intervention Type DRUG

Other Intervention Names

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Life Pak Nano

Eligibility Criteria

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Inclusion Criteria

* Nonpregnant Females, age 18-30 or 50-70
* Body Mass Index Normal or Overweight
* If age 18-30, must be non-smoker

Exclusion Criteria

* Use of anti-aging medications within 3 months of enrollment
* Use of over-the-counter anti-aging creams (not sunscreens) more than once per week within one month of enrollment
* Use of dietary supplements including vitamins within one month of enrollment
* Use of tanning beds or excessive UV exposure (greater than 2 hours per day) within one month of enrollment
* Use of sunless tanners within one month of enrollment
* Uncontrolled or ongoing serious medical condition
* Participation in another clinical study involving use of an investigational drug or product
* Medical condition which, at the discretion of the investigator, will have a significant impact on ability to judge participant's skin characteristics, including age.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Nu Skin Enterprises

INDUSTRY

Sponsor Role collaborator

Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Anne Chang

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dr. Anne Lynn S. Chang

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Locations

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Stanford University School of Medicine

Stanford, California, United States

Site Status

Countries

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United States

References

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Spitale RC, Cheng MY, Chun KA, Gorell ES, Munoz CA, Kern DG, Wood SM, Knaggs HE, Wulff J, Beebe KD, Chang AL. Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers. Genome Med. 2012 Feb 23;4(2):14. doi: 10.1186/gm313.

Reference Type RESULT
PMID: 22360970 (View on PubMed)

Other Identifiers

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10622

Identifier Type: -

Identifier Source: org_study_id