Efficacy of Flash Glucose-Sensing Technology on the Occurrence of Cardiac Arrhythmias Associated With Hypoglycemia

NCT ID: NCT03570138

Last Updated: 2020-10-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-06-29

Study Completion Date

2021-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Hypoglycemia, frequently asymptomatic, may lead to cardiac arrythmias and induce an increased risk of cardiovascular morbidity and mortality in patients with type 2 diabetes (T2D). The study hypothesize is that the hypoglycemia reduction, achieved with the FREESTYLE LIBRE device, a Glucose Continuous Monitoring system, may decrease cardiac arrythmias associated with hypoglycemia. So the main objective is to evaluate the efficacy of the FREESTYLE LIBRE system, associated with a specific therapeutic education on the cardiac arrythmias reduction, compared to a capillary ASG system with standard therapeutic education, in patient with T2D with high risk of hypoglycemia.

This is a open, multicenter, controlled, randomized study in parallel group.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Insulin Treated Type 2 Diabetes With High Risk of Hypoglycemia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Flash continuous glucose monitoring system

Participants will wear the FREESTYLE LIBRE device and receive a specific therapeutic education for its use.

Group Type EXPERIMENTAL

FREESTYLE LIBRE device, a Flash Continuous Glucose Monitoring System

Intervention Type DEVICE

Specific therapeutic education for diabetes self management

Standard self monitoring blood glucose system

Participants will use their own usual self monitoring blood glucose system and receive a C They will wear a masked FREESTYLE LIBRE Pro system.

Group Type ACTIVE_COMPARATOR

Usual self monitoring Blood Glucose device

Intervention Type DEVICE

Standard therapeutic education for diabetes self management

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

FREESTYLE LIBRE device, a Flash Continuous Glucose Monitoring System

Specific therapeutic education for diabetes self management

Intervention Type DEVICE

Usual self monitoring Blood Glucose device

Standard therapeutic education for diabetes self management

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Type 2 diabetes (diagnosis based on the World Health Organization criteria)
* Treatment with insulin therapy (continuous subcutaneous insulin Infusion or more than 1 daily injection)
* Resting heart beat ≥ 60bpm
* High risk of hypoglycemia defined as :

* Estimated glomerular filtration rate 15-59 ml/min/1.73 m² (according to CKD-EPI formula)
* Or history of stable proliferative diabetic retinopathy
* Or body mass index ≤ 30 kg/m²
* Or history of severe hypoglycemia in the previous 6 months
* Or history of non-severe ≤70mg/dL hypoglycemia in the previous 4 weeks

Exclusion Criteria

* Type 1 diabetes mellitus or diabetes due to other cause
* History of atrial fibrillation
* Pacemaker
* Estimated glomerular filtration rate \<15 ml/min/1.73 m² (according to CKD-EPI formula)
* Currently using a flash continuous Glucose Monitoring device
* In the investigator's opinion, acute or chronic medical condition considered as unsuitable for inclusion in the study .
Minimum Eligible Age

45 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Poitiers University Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

University Hospital, Bordeaux

Bordeaux, , France

Site Status RECRUITING

University Hospital, Limoges

Limoges, , France

Site Status RECRUITING

University Hospital, Nantes

Nantes, , France

Site Status RECRUITING

Hospital, Niort

Niort, , France

Site Status NOT_YET_RECRUITING

Hospital, Pau

Pau, , France

Site Status RECRUITING

University Hospital, Poitiers

Poitiers, , France

Site Status RECRUITING

University Hospital, Toulouse

Toulouse, , France

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

France

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

SAULNIER Pierre-Jean, Prof.

Role: CONTACT

+33 549444689

BONNIN Marie, Project chief

Role: CONTACT

+33 549443317

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

SPIDER-STYLE

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

FreeStyle Libre in Pregnancy Study
NCT02665455 COMPLETED NA
Accuracy of Freestyle Libre
NCT02734745 UNKNOWN NA