Evaluation of Flash Continuous Glucose Monitoring to Reduce Hyperglycemia in People With T2 Diabetes

NCT ID: NCT04843527

Last Updated: 2025-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

350 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-04-02

Study Completion Date

2025-06-30

Brief Summary

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A multi-center, randomized, prospective, non-significant risk study to compare the impact of the FreeStyle Libre Flash Glucose Monitoring System with and without a food logging smartphone application on reducing time above 180 mg/dL in subjects with type 2 diabetes who are not adequately controlled on their existing oral anti-diabetes medication regimen.

Detailed Description

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Approximately 350 subjects will be enrolled to obtain at least 84 randomized subjects,approximately 42 subjects per arm. Subjects will be randomized to use either the FreeStyle Libre Flash Glucose Monitoring System or FreeStyle Libre Flash Glucose Monitoring System with a food logging smartphone application to manage their diabetes.

The subsequent impact on reducing the amount of time spent above 180 mg/dL will be assessed.

Conditions

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Diabetes Mellitus, Type 2

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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FreeStyle Libre

Subjects will be randomized to use the FreeStyle Libre Flash Glucose Monitoring System to manage their diabetes.

Group Type ACTIVE_COMPARATOR

FreeStyle Libre System

Intervention Type DEVICE

FreeStyle Libre Flash Glucose Monitoring System

FreeStyle Libre plus food logging

Subjects will be randomized to use the FreeStyle Libre Flash Glucose Monitoring System and a food logging smartphone application to manage their diabetes.

Group Type ACTIVE_COMPARATOR

FreeStyle Libre System plus food app

Intervention Type DEVICE

FreeStyle Libre Flash Glucose Monitoring System and Smartphone Food Logging application

Interventions

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FreeStyle Libre System

FreeStyle Libre Flash Glucose Monitoring System

Intervention Type DEVICE

FreeStyle Libre System plus food app

FreeStyle Libre Flash Glucose Monitoring System and Smartphone Food Logging application

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subject must be at least 18 years of age.
* Subject has been diagnosed with type 2 diabetes.
* HbA1c greater than or equal to 7.5% and less than or equal to 12%
* Subject is on at least 1 diabetes medication in the classes of metformin, SGLT-2 inhibitors, GLP-1 agonists and DPP-4 inhibitors.
* Subject owns a compatible smartphone
* Subject agrees to a 3-month period of no diabetes medication changes.
* Subject is willing to make diet and lifestyle changes in response to education and glucose data

Exclusion Criteria

* Subject is currently on insulin therapy or sulfonylurea-based medications.
* Subject has known allergy to medical grade adhesive or isopropyl alcohol used to disinfect skin.
* Subject is known to be pregnant at the time of study enrollment (applicable to female subjects only).
* Subject has extensive skin changes/diseases at the proposed application sites that could interfere with device placement or the accuracy of interstitial glucose measurements.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Diabetes Care

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Shridhara A Karinka, PhD

Role: STUDY_DIRECTOR

Abbott Diabetes Care Inc

Locations

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Boston Medical Center

Boston, Massachusetts, United States

Site Status

Henry Ford Health System

Detroit, Michigan, United States

Site Status

HealthPartners Institute dba International Diabetes Center

Minneapolis, Minnesota, United States

Site Status

UMPC

Pittsburgh, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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ADC-US-RES-19185

Identifier Type: -

Identifier Source: org_study_id

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