Effect of Orange Juice on Glycemic Response

NCT ID: NCT03522896

Last Updated: 2018-06-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-30

Study Completion Date

2018-06-27

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Orange juice naturally contains high concentrations of hesperidin, which affects glucose absorption in in vitro experiments. This study is to test if hesperidin and other components of orange juice (not other sugars or organic acids) affect the post-prandial blood glucose concentration derived from sugars already present in the orange juice.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Healthy volunteers will consume orange juice with added water or food-grade hesperidin.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Effect of Food on Postprandial Hyperglycemia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

control meal

glucose, fructose, sucrose, malic acid and citric acid in water

Group Type PLACEBO_COMPARATOR

control

Intervention Type OTHER

balancing sugars and organic acids

test meal 1

orange juice with added hesperidin (low dose)

Group Type EXPERIMENTAL

test meal 1

Intervention Type OTHER

orange juice plus hesperidin low dose

test meal 2

orange juice with added hesperidin (high dose)

Group Type EXPERIMENTAL

test meal 2

Intervention Type OTHER

orange juice plus hesperidin higher dose

test meal 3

diluted orange juice with added hesperidin

Group Type EXPERIMENTAL

test meal 3

Intervention Type OTHER

diluted orange juice plus hesperidin low dose

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

control

balancing sugars and organic acids

Intervention Type OTHER

test meal 1

orange juice plus hesperidin low dose

Intervention Type OTHER

test meal 2

orange juice plus hesperidin higher dose

Intervention Type OTHER

test meal 3

diluted orange juice plus hesperidin low dose

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* fasting blood glucose below 5.9 mM

Exclusion Criteria

* fasting glucose above 6 mM pregnant
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University of Leeds

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Gary Williamson

Prof

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

University of Leeds

Leeds, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United Kingdom

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

MEEC15-044b

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.