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Bioavailability of Carotenoids and Flavonoids From Fresh Oranges and Orange Juice.

NCT ID: NCT02380144

Last Updated: 2016-11-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-01-31

Study Completion Date

2017-07-31

Brief Summary

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The study was designed as a randomized 2-way cross-over study to assess the bioavailability of carotenoids and flavonoids from sweet oranges and orange juice. Volunteers followed a wash-out period for 2 weeks prior to eating either 400 g of fresh oranges or 719 g of orange juice. The amount of test food was adjusted to deliver an equal amount of β-cryptoxanthin (740 µg). After a consecutive wash-out period of 2 weeks, the procedure was repeated and the volunteers ingested the complementary test food. Blood samples were collected at 8 time points up to 9.5 h after test meal consumption. Additionally, 24 h-urine was collected to evaluate flavonoid recovery.

Detailed Description

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Conditions

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Healthy

Keywords

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carotenoid bioavailability beta-cryptoxanthin flavonoid hesperidin narirutin randomized cross-over Pharmacokinetics micronutrients Oranges/Orange Juice

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Orange Fruit - Orange Juice

Sequence of test foods during the intervention period:

1st: Orange fruit; 2nd: Orange juice

Group Type EXPERIMENTAL

Fresh orange fruit and pasteurized fruit juice

Intervention Type OTHER

Orange Juice - Orange Fruit

Sequence of test foods during the intervention period:

1st: Orange juice; 2nd: Orange fruit

Group Type EXPERIMENTAL

Fresh orange fruit and pasteurized fruit juice

Intervention Type OTHER

Interventions

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Fresh orange fruit and pasteurized fruit juice

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy adult men and women
* BMI: 17-60
* Age: 18-65

Exclusion Criteria

* Women who are lactating or pregnant or plan to be pregnant
* Individuals using tobacco products
* Individuals with metabolic or malabsorption disorders
* Individuals with a history of cancer
* Individuals with a history of liver insufficiency
* Individuals with a history of chronic and lipid metabolism-related diseases
* Individuals with an allergy to oranges
* Obese individuals (BMI \> 30)
Minimum Eligible Age

23 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Hohenheim

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Reinhold Carle, Prof. Dr.

Role: PRINCIPAL_INVESTIGATOR

University of Hohenheim

Locations

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Chair of Plant Foodstuff Technology and Analysis (150d), University of Hohenheim

Stuttgart, Baden-Wurttemberg, Germany

Site Status

Countries

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Germany

References

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Aschoff JK, Rolke CL, Breusing N, Bosy-Westphal A, Hogel J, Carle R, Schweiggert RM. Bioavailability of beta-cryptoxanthin is greater from pasteurized orange juice than from fresh oranges - a randomized cross-over study. Mol Nutr Food Res. 2015 Oct;59(10):1896-904. doi: 10.1002/mnfr.201500327. Epub 2015 Jul 20.

Reference Type RESULT
PMID: 26114420 (View on PubMed)

Other Identifiers

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F-2013-097

Identifier Type: -

Identifier Source: org_study_id