Neural Bases of the Check Process

NCT ID: NCT03483233

Last Updated: 2025-12-29

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 51 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-11-23
• Study Completion Date: 2020-01-16

Brief Summary

Effective exploration of the environment, check for information to improve one's own performance, are fundamental abilities of human cognition. These abilities are dependent on the process of cognitive control.

However, they are clearly impaired and uncontrollable in certain behavioral disorders such as obsessive-compulsive disorder (OCD). Compulsive checks of these patients, spontaneously associated with a feeling of intense uncertainty, suggest disturbances of evaluative and metacognitive functions. However, no biological observations have yet been able to feed these hypotheses.

The evaluation of decisions and actions involves the middle cingulate cortex (MCC) (which belongs to a cortico-subcortical network structurally and functionally altered in OCD patients). Cingulotomy has long been used as a therapy in severe OCD, with However, the precise part of the cingulate cortex that contributes to check (and its pathological forms) remains to be discovered.

The purpose of this research campaign is to determine, through functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) in healthy human subjects:

1. the location and role of the MCC region involved in normal check decision processes,

2. determine the identity of the entire network involved

Conditions

Healthy Volunteers

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

fMRI and EEG study

Group Type: EXPERIMENTAL

fMRI and EEG study

Intervention Type: OTHER

fMRI and EEG study

Interventions

fMRI and EEG study

fMRI and EEG study

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• adults age range 20-45 years
• being able to provide a written consent form
• having a social insurance
• have a normal vision (with or without corrections)
• Right-handed

Exclusion Criteria

• Subjects with MRI contraindications (e.g. pacemaker, claustrophobia, metal in the body, etc…).
• Pregnant subjects
• Subjects with neurological history
• Subjects must be willing to be advise in case of discovery of brain abnormality.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Hospices Civils de Lyon

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Emmanuel Procyk

Role: PRINCIPAL_INVESTIGATOR

INSERM U1208

Locations

Inserm U1208

Bron, , France

Countries

France

References

Stoll FM, Fontanier V, Procyk E. Specific frontal neural dynamics contribute to decisions to check. Nat Commun. 2016 Jun 20;7:11990. doi: 10.1038/ncomms11990.

Reference Type: RESULT

PMID: 27319361 (View on PubMed)

Other Identifiers

2018-A00405-50

Identifier Type: OTHER

Identifier Source: secondary_id

69HCL17_0143

Identifier Type: -

Identifier Source: org_study_id