Neural Correlates of Compulsivity

NCT ID: NCT05195476

Last Updated: 2024-05-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 41 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-12-17
• Study Completion Date: 2024-02-28

Brief Summary

This study aims to collect data from individuals with obsessive-compulsive disorder (OCD) and healthy controls in order to clarify how learning strategies are employed differently by individuals with compulsive psychopathology and healthy individuals. Behavioral and electroencephalogram (EEG) data will be collected during one experimental reinforcement learning tasks from participants diagnosed with OCD (n = 30) and healthy controls (n = 30). Computational modeling, an advanced data analytic approach that can directly link neural measures with behavior, will be used to quantify learning processes. These parameters then will be related to measures of neural events obtained using EEG, a neuroimaging method that has high temporal resolution, to test for evidence of neurocognitive alterations.

Detailed Description

Learning and decisions making are thought to be directed by multiple parallel cognitive systems. These systems account for automatic, inflexible responding to stimuli, as well as more deliberate, effortful representations of relationships in an environment. It has long been suggested than an imbalance in these cognitive control systems explains the emergence of compulsivity, a trait in which behaviors persist despite adverse outcomes. Compulsivity is a characteristic of a number of psychological disorders, however, current theories of how abnormalities in cognitive systems involved in learning and decision making lead to the onset of these disorders remain incomplete.

Conditions

Obsessive-Compulsive Disorder

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Individuals diagnosed with OCD

Individuals diagnosed with OCD

No interventions assigned to this group

Healthy controls

Individuals who have not been diagnosed with any psychiatric disorders

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Between 18-50 years of age
• English-speaking
• Capacity to provide informed consent
• Primary diagnosis of OCD with at least moderate severity

Exclusion Criteria

• Current or lifetime history of psychiatric disorders other than OCD that may increase the risk of participation
• History of any significant medical condition that may increase the risk of participation
• Alcohol or substance use disorder in the past year
• Exposure and response prevention for OCD within the last six weeks
• Currently taking psychotropic medication

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

International OCD Foundation

UNKNOWN

Sponsor Role: collaborator

Columbia University

OTHER

Sponsor Role: lead

Responsible Party

Amy Rapp

Assistant Professor of Clinical Medical Psychology (in Psychiatry)

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Amy Rapp, PhD

Role: PRINCIPAL_INVESTIGATOR

Columbia University

Locations

New York State Psychiatric Institute

New York, New York, United States

Countries

United States

Other Identifiers

7867

Identifier Type: -

Identifier Source: org_study_id