Serum Carotenoids and Risk of Gastrointestinal Tract Cancer: Meta-analysis of Ten Studies

NCT ID: NCT03433092

Last Updated: 2018-02-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40641 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-11-01

Study Completion Date

2017-12-28

Brief Summary

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Previous studies have suggested that serum carotenoids may be associated with risk of gastrointestinal tract cancer (GIT cancer), but the results were inconsistent. Thus, the investigators conducted a meta-analysis to evaluate the associations between serum carotenoids and risk of GIT cancer.

Detailed Description

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Conditions

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Gastrointestinal Tract Cancer

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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Jing Huang et. al, 2017

serum carotenoids

Intervention Type OTHER

In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

Max Leenders et. al,2014

serum carotenoids

Intervention Type OTHER

In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

Yusuke Okuyama et. al,2014

serum carotenoids

Intervention Type OTHER

In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

GC Kabat et. al,2012

serum carotenoids

Intervention Type OTHER

In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

Christina Persson et. al,2008

serum carotenoids

Intervention Type OTHER

In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

M Jenab et. al,2006

serum carotenoids

Intervention Type OTHER

In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

Kenji Wakai et. al,2005

serum carotenoids

Intervention Type OTHER

In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

Christian C. Abnet et. al,2003

serum carotenoids

Intervention Type OTHER

In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

N Malila et. al,2002

serum carotenoids

Intervention Type OTHER

In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

G Pappalardo et. al,1997

serum carotenoids

Intervention Type OTHER

In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

Interventions

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serum carotenoids

In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* The study had both case and control groups
* Serum carotenoids levels, relative risk (RR) or OR and corresponding 95% CI were reported
* Patients in case group were diagnosed with GIT cancer

Exclusion Criteria

·Animal studies
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sichuan Provincial Science and Technology Support Project (2016SZ0047)

UNKNOWN

Sponsor Role collaborator

Yong Zhou

OTHER

Sponsor Role lead

Responsible Party

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Yong Zhou

West China Hospital

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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West China Hospital, Sichuan University

Chengdu, Sichuan, China

Site Status

Countries

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China

References

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Huang J, Lu MS, Fang YJ, Xu M, Huang WQ, Pan ZZ, Chen YM, Zhang CX. Serum carotenoids and colorectal cancer risk: A case-control study in Guangdong, China. Mol Nutr Food Res. 2017 Oct;61(10). doi: 10.1002/mnfr.201700267. Epub 2017 Jul 31.

Reference Type RESULT
PMID: 28605127 (View on PubMed)

Other Identifiers

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2759067085

Identifier Type: -

Identifier Source: org_study_id

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