Dietary Patterns, Metabolomics and Colorectal Cancer Risk

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

173230 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-06-01

Study Completion Date

2022-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in American men and women with ≥130,000 new cases each year. Several dietary patterns have been associated with CRC risk but underlying mechanisms are not fully understood. Researchers thus propose to integrate dietary patterns and metabolomics data to comprehensively investigate biological pathways linking dietary patterns and CRC risk.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Nutrition and Lifestyle Study Cohort of Colorectal Cancer in China

NCT02215642

Colorectal Cancer

UNKNOWN

Association of Colorectal Cancer With Nutrition, Diet, Obesity, Diabetes Mellitus, and Genetic Alterations in Taiwan

NCT00172757

Colorectal Cancer

UNKNOWN

Do Patients With Colorectal Cancer Understand That Their Family is at Risk?

NCT00145860

Colorectal Cancer

TERMINATED

Alcohol Intake, Alcohol Metabolizing Enzymes Gene Polymorphisms and the Risk of Colorectal Cancer

NCT03155542

Colorectal Neoplasms

COMPLETED

Gut Mucosal Microbiota is Associated With Colorectal Cancer Relapse

NCT03385213

Gut Microbiota Colorectal Cancer

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Several dietary patterns have been associated with colorectal cancer (CRC) risk but underlying mechanisms are not fully understood. Also, evidence is lacking on the consistency of dietary guidelines for overall health and CRC prevention given that it is not feasible to have an optimal diet for every disease. Furthermore, metabolomic profiling has not been widely assessed with respect to CRC risk. Metabolomics is uniquely suited to assess metabolic responses to dietary stimuli, given that it is situated downstream to all the other "omics". Building on prior work in hypothesis-driven dietary patterns and CRC prevention, the researchers seek to fill these knowledge gaps by proposing to: 1) use a standardized methodology to compare the best diet for overall health with the best diet for CRC prevention, and further determine if any associations of dietary patterns with CRC prevention are mediated by mechanisms involving inflammation and insulin; 2) determine metabolites that may mediate the association of dietary intake with CRC risk. The researchers will utilize two large prospective cohort studies, the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS), in which dietary and nondietary data have been collected every 2 to 4 years among 173,230 women and men over the last ≥30 years, with ≥3,400 CRC cases and ≥43,800 all-cause deaths. This integrated interrogation of dietary patterns and metabolomics data will inform the design of guidelines for healthful lifestyles that are optimized for CRC prevention.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Colorectal Cancer Mortality

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Men-observed dietary pattern

Health Professionals Follow-up Study: a prospective cohort of male health professionals

Observed dietary pattern

Intervention Type OTHER

No intervention will be used. This is an observational study with dietary patterns as main exposure

Women-observed dietary pattern

Nurses' Health Study: a prospective cohort of female registered nurses

Observed dietary pattern

Intervention Type OTHER

No intervention will be used. This is an observational study with dietary patterns as main exposure

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Observed dietary pattern

No intervention will be used. This is an observational study with dietary patterns as main exposure

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

-Adult health professionals

Exclusion Criteria

* Any cancer except nonmelanoma skin cancer
* Did not complete a food frequency questionnaire during follow-up
* Had implausible values for total energy intake (\<600 or \>3500 kcal/d for women and \<800 or \>4,200 kcal/d for men) at study entry

Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes