Study of the Association of Nonalcoholic Fatty Liver Disease With Colorectal Malignant Neoplasm

NCT ID: NCT01657773

Last Updated: 2012-08-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 2315 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-04-30
• Study Completion Date: 2012-07-31

Brief Summary

The aim of this sudy is to investigate the prevalence of colorectal cancer (CRC) in patients with nonalcoholic fatty liver disease (NAFLD) and evaluate whether NAFLD is a risk factor for CRC.

Detailed Description

As one of the most common cancer worldwide, colorectal cancer (CRC) is a major cause of cancer death in Asian countries. And during the past three decades, the incidence of CRC has been increasing rapidly in china. Many studies supported that cigarette smoking, obesity and insulin resistance were associated with CRC. In recent years, metabolic syndrome (MetS) - Including glucose tolerance, dyslipidemia, obesity, hypertension and chronic inflammation - and its individual components have been proven to be the risk for colorectal neoplasm. Colonoscopy is the most accurate technique for diagnosis, surveillance and exclusion of colorectal neoplasm for high-risk CRC groups. Therefore, improved risk stratification knowledge of the target population is necessary to improve CRC patients' prognosis.

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide and cause a wide spectrum of liver damage, such as steatohepatitis, cirrhosis, even end-stage liver disease and hepatocellular carcinoma. NAFLD has been found to be associated with obesity, insulin resistance, hypertension and dyslipidemia, and is considered as a liver manifestation of MetS. Although it has been also well established that MetS and its individual components are risk factors for colorectal neoplasm, as above, there is paucity of research looking at the relation between NAFLD and CRC. Therefore, the investigators aimed to investigate the prevalence of CRC in patients with NAFLD and evaluate whether NAFLD is an independent risk factor for CRC.

Conditions

Colorectal Neoplasms; Nonalcoholic Fatty Liver Disease

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

colorectal cancer, without nonalcoholic fatty liver disease

Patients were performed colonoscopy examination for colorectal cancer and who had been foud colorectal cancer proven by biopsy.Then the colorectal cancer patients who had not been diagnosed with nonalcoholic fatty liver disease was based on blood tests and abdomen ultrasound examination.

Ultrasound examination and Colonoscopy examination

Intervention Type: OTHER

colorectal cancer, with nonalcoholic fatty liver disease

Patients were performed colonoscopy examination for colorectal cancer and who had been foud colorectal cancer proven by biopsy.Then the colorectal cancer patients who had been diagnosed with nonalcoholic fatty liver disease was based on blood tests and abdomen ultrasound examination ultrasonography.

Ultrasound examination and Colonoscopy examination

Intervention Type: OTHER

Interventions

Ultrasound examination and Colonoscopy examination

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patients had colonoscopy and
• Patients had conventional inspections(blood routine, liver function test and abdomen B ultrasonography)

Exclusion Criteria

• Patients were excluded with history of colorectal cancers or polyps, other extraintestinal malignancies and contraindications to colonoscopy.
• Patients were excluded who had viral hepatitis, cirrhosis, liver cancer or other liver disease.
• Patients ere excluded who drank more than 20g alcohol per day.

• Minimum Eligible Age: 10 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Wenzhou Medical University

OTHER

Sponsor Role: lead

Responsible Party

Ming-Hua Zheng

Attending physician

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

MingHua Zheng, Medical Master

Role: STUDY_CHAIR

First Affiliated Hospital of Wenzhou Medical College

XianFeng Lin, Medical undergraduate

Role: PRINCIPAL_INVESTIGATOR

Wenzhou Medical University

KeQing Shi, Medical Master

Role: PRINCIPAL_INVESTIGATOR

First Affiliated Hospital of Wenzhou Medical College

WenYue Liu, Medical undergraduate

Role: PRINCIPAL_INVESTIGATOR

First Affiliated Hospital of Wenzhou Medical College

Locations

Wenzhou Medical College

Wenzhou, Zhejiang, China

Countries

China

References

Lin XF, Shi KQ, You J, Liu WY, Luo YW, Wu FL, Chen YP, Wong DK, Yuen MF, Zheng MH. Increased risk of colorectal malignant neoplasm in patients with nonalcoholic fatty liver disease: a large study. Mol Biol Rep. 2014 May;41(5):2989-97. doi: 10.1007/s11033-014-3157-y. Epub 2014 Jan 22.

Reference Type: DERIVED

PMID: 24449368 (View on PubMed)

Other Identifiers

wenzhouMC 001

Identifier Type: -

Identifier Source: org_study_id