Alcohol Intake, Alcohol Metabolizing Enzymes Gene Polymorphisms and the Risk of Colorectal Cancer

NCT ID: NCT03155542

Last Updated: 2017-05-23

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 140 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-12-31
• Study Completion Date: 2017-03-29

Brief Summary

According to the statistic reports from World Health Organization (WHO) International Agency for Research on Cancer (IARC), the incidence and mortality rate of colorectal cancer ranked third and fourth respectively among ten most commonly diagnosed cancer worldwide; moreover, based on the statistics from Health Promotion Administration, Ministry of Health and Welfare in Taiwan, the incidence and mortality rate of colorectal cancer ranked second and third respectively among call cancer in Taiwanese population. However, if colorectal cancer is diagnosed and treated in early phase, the 5-year survival rate for stage I colorectal cancer can be up to 90%; on the other hand, the 5-year survival rate for end stage colorectal cancer is only approximately 10%. Therefore, the screening, early diagnosis od colorectal cancer is crucial. To date, there are some known risk factors for colorectal cancer, including familial adenomatous polyposis, obesity, physical inactivity, etc. Alcohol had also been identified as an important risk factor for colorectal cancer, and the risk could be higher among Asian population because of the reduced enzymatic activity of some of the alcohol metabolizing enzymes. Thus, through this study, the investigators hope to find out the risk factors of colorectal cancer among Taiwanese population, including alcohol metabolizing enzyme gene polymorphisms and their interaction with environmental factors, to attain the purpose of early prevention of colorectal cancer.

Detailed Description

The purpose of this study is to find out relationship between alcohol metabolizing enzyme gene polymorphism and colorectal cancer, and discuss the impact of the interaction between gene polymorphism and environmental factors on the risk of colorectal cancer.

Conditions

Colorectal Neoplasms

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: RETROSPECTIVE

Study Groups

colorectal cancer patient case group

Histologically confirmed colorectal adenocarcinoma

No interventions assigned to this group

family member control group

without the diagnosis of CRC and accompanied the patient to the primary care clinic visit

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

Case:

• Histologically confirmed colorectal adenocarcinoma at National Taiwan University Hospital (NTUH) from 2000 to 2016
• Age >20 at the time of inclusion

Control:

• No diagnosis of colorectal cancer
• Age >20 at the time of inclusion
• Family members of case, including parents, siblings, offspring, spouse mother-in-law or daughter-in-law

Exclusion Criteria

• History of familial adenomatous polyposis
• History of partial or total removal of the colorectum
• History of inflammatory bowl disease
• History of malignant neoplasms

• Minimum Eligible Age: 20 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Taiwan University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Yen-Hui CHEN

Role: PRINCIPAL_INVESTIGATOR

Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University

Locations

National Taiwan University Hospital

Taipei, ROC, Taiwan

Countries

Taiwan

Other Identifiers

201610059RIND

Identifier Type: -

Identifier Source: org_study_id