Are Sporadic Colorectal Cancers in Young Distinct From Elderly?

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1599 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-11-11

Study Completion Date

2022-08-02

Brief Summary

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In this study, the investigators compared and evaluated the clinicopathological and oncological characteristics of sporadic colorectal cancer (CRC) in young adults without genetic mutations associated with hereditary CRC syndrome and sporadic CRC in elderly individuals.

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Detailed Description

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The ambiguity in the findings among several previous studies might be because of the difference in the age of the study population, yCRC and eCRC. The family history of CRC and cancer due to Crohn's disease or ulcerative colitis were also not excluded in such previous studies. Most importantly, those studies did not rule out the risk of hereditary cancer through the genetic testing in yCRC. Since hereditary CRC accounts for approximately 34% of those under the age of 35 years, it is necessary to exclude it to accurately compare the clinicopathological characteristics of sporadic cancer developed in yCRC and eCRC.

Conditions

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Colorectal Neoplasms

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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young colorectal cancer (yCRC)

1. histologically confirmed cases of adenocarcinoma in the colon and rectum
2. the age at the time of diagnosis should be ≤ 40 years

No interventions assigned to this group

elderly colorectal cancer (eCRC)

1. histologically confirmed cases of adenocarcinoma in the colon and rectum
2. the age at the time of diagnosis should be ≥ 70 years

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Histologically confirmed cases of adenocarcinoma in the colon and rectum
* The age at the time of diagnosis should be ≤ 40 years (for yCRC) or ≥ 70 years (for eCRC)
* Genetic testing confirmation of non-hereditary cancer.

Exclusion Criteria

* Inflammatory bowel disease
* A family history of CRC
* A history of other cancers
* Underwent any emergency operation or palliative surgery
* The Amsterdam criteria with mutations in genes associated with APC, MLH1, MSH2, MSH6

Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No