P-wave Terminal Force in Patients With Atrial Fibrillation.

NCT ID: NCT03428971

Last Updated: 2020-01-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-03-01

Study Completion Date

2020-12-07

Brief Summary

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It is suggested that P-wave terminal force (Ptf), a product of the amplitude (PAM) and the duration (PT) of the terminal phase of P-wave in lead V1, shows early delay in left atrial conduction, observed earlier that the dilatation of left atrium.

The aim is to follow PT, PAM and Ptf changes during 5-year follow-up (5FU) and examine the relation of these changes to the number of AF episodes requiring hospitalisation (HOSP) for restoration of sinus rhythm (RSR).

Detailed Description

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Background. It is suggested that P-wave terminal force (Ptf), a product of the amplitude (PAM) and the duration (PT) of the terminal phase of P-wave in lead V1, shows early delay in left atrial conduction, observed earlier that the dilatation of left atrium.

Aim. We aim to follow PT, PAM and Ptf changes during 5-year follow-up (5FU) and examine the relation of these changes to the number of AF episodes requiring hospitalisation (HOSP) for restoration of sinus rhythm (RSR).

We hypothesise that, in patients with atrial fibrillation (AF):

1. the index parameters (PT, PAM, Ptf), characterising left atrial repolarization, correlates the number of future hospitalisations (HOSP) aimed for restoration of sinus rhythm (RSR) in 5-year follow-up (5FU)
2. in 5FU the number of HOSP aimed for RSR correlates with the progression of left atrium electrical remodelling, expressed as PAM5,PT5, Ptf5 at 5FU.

Conditions

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Atrial Fibrillation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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cardioversion

Direct current (DC) cardioversion for sinus rhythm restoration

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* documented atrial fibrillation at admission
* successful restoration of sinus rhythms documented in 12-leads ECG,
* follow-up =\> 5 years

Exclusion Criteria

* arrhythmia other than atrial fibrillation at admission,
* unsuccessful restoration of sinus rhythms,
* successful restoration of sinus rhythms but missing 12-leads ECG recording,
* previous ablation/operation within left atrium,
* follow-up \< 5 years
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medical University of Lublin

OTHER

Sponsor Role lead

Responsible Party

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Maciej Wójcik, MD, PhD

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Maciej Wójcik, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Medical University of Lublin, Poland

Locations

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Medical University of Lublin

Lublin, , Poland

Site Status RECRUITING

Countries

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Poland

Central Contacts

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Maciej Wójcik, MD, PhD

Role: CONTACT

+48817244151

Facility Contacts

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Maciej Wójcik, MD, PhD

Role: primary

+48817244151

References

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Wojcik M, Kuniss M, Berkowitsch A, Neumann T. P-wave terminal force and atrial fibrillation: a lesson learned from old masters. Rev Esp Cardiol (Engl Ed). 2012 Jun;65(6):584-5; author reply 585. doi: 10.1016/j.recesp.2012.01.015. Epub 2012 Mar 31. No abstract available.

Reference Type BACKGROUND
PMID: 22465604 (View on PubMed)

Janin S, Wojcik M, Kuniss M, Berkowitsch A, Erkapic D, Zaltsberg S, Ecarnot F, Hamm CW, Pitschner HF, Neumann T. Pulmonary vein antrum isolation and terminal part of the P wave. Pacing Clin Electrophysiol. 2010 Jul;33(7):784-9. doi: 10.1111/j.1540-8159.2010.02754.x. Epub 2010 Mar 29.

Reference Type BACKGROUND
PMID: 20374516 (View on PubMed)

Ishida K, Hayashi H, Miyamoto A, Sugimoto Y, Ito M, Murakami Y, Horie M. P wave and the development of atrial fibrillation. Heart Rhythm. 2010 Mar;7(3):289-94. doi: 10.1016/j.hrthm.2009.11.012. Epub 2009 Nov 12.

Reference Type BACKGROUND
PMID: 20133209 (View on PubMed)

Martin Garcia A, Jimenez-Candil J, Hernandez J, Martin Garcia A, Martin Herrero F, Martin Luengo C. P wave morphology and recurrence after cardioversion of lone atrial fibrillation. Rev Esp Cardiol (Engl Ed). 2012 Mar;65(3):289-90. doi: 10.1016/j.recesp.2011.04.023. Epub 2011 Jul 30. No abstract available. English, Spanish.

Reference Type BACKGROUND
PMID: 21803476 (View on PubMed)

Other Identifiers

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MW-MULublin-1

Identifier Type: -

Identifier Source: org_study_id

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