The Th17/Treg Cells and IL-23/IL-17 Axis and Early Enteral Nutrition in Sepsis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

53 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-01

Study Completion Date

2018-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The investigators aim to evaluate the roles of Th17/Treg cells and IL-23/IL-17 axis in the mechanisms of early enteral nutrition (EEN) correcting immune imbalance of sepsis by means of improving the intestinal flora disturbance. The results of this study would lay the foundation for revealing the mechanisms of EEN improving immune imbalance of sepsis and provide a new idea to the early treatment of sepsis

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Th9/IL-9 and Early Enteral Nutrition in Sepsis

NCT03791866

Sepsis Intestinal Mucosal Barrier Th9 Cells +1 more

UNKNOWN NA

Comparison of Short Peptide and Whole Protein Formula in the Early Enteral Nutrition of Patients With Sepsis

NCT07038057

Sepsis Nutrition

NOT_YET_RECRUITING NA

the Effect of Gut Microbiota on the Prognosis of Sepsis

NCT02768324

Sepsis

UNKNOWN

Metabolism of Branched-chain Amino Acids in Monocyte/Macrophage During Sepsis

NCT03842371

Sepsis Syndrome

UNKNOWN

PD-1/PD-L1 Pathway Study on Septic Patients

NCT01161745

Sepsis

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Sepsis Immune System Disorder Enteral Feeding

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

early enteral nutrition

Group Type EXPERIMENTAL

enteral nutrition

Intervention Type OTHER

early enteral nutrition group or delayed enteral nutrition group

delayed enteral nutrition

Group Type ACTIVE_COMPARATOR

enteral nutrition

Intervention Type OTHER

early enteral nutrition group or delayed enteral nutrition group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

enteral nutrition

early enteral nutrition group or delayed enteral nutrition group

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Clinical diagnosis of sepsis
2. Within 3 days of sepsis onset before ICU admission
3. No artificial nutrition (enteral or parenteral nutrition) were provided before ICU admission

Exclusion Criteria

1. Ileus
2. Digestive tract hemorrhage
3. Inflammatory bowel disease
4. Abdominal hypertension (IAP \>25mmHg)
5. Cancer or chronic organ dysfunction (e.g., hepatic or renal dysfunction)
6. Malnutrition or immunodeficiency
7. Long-term use of hormones

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No