Metabolism of Branched-chain Amino Acids in Monocyte/Macrophage During Sepsis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-02-11

Study Completion Date

2022-02-28

Brief Summary

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The current project was designed to examine the metabolic level of branched-chain amino acids in plasm and monocyte/macrophage, and its role in immune dysfunction during sepsis.

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Detailed Description

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In this study, the investigators will collect the peripheral blood of 1,3,7,14 day after diagnose of sepsis. Then, the concentration of branched-chain amino acids(BCAAs) in monocytes and plasma, and the expression of BCAAs metabolic enzymes in monocytes will be determined. Additionally, the inflammatory cytokines, e.g., Interleukin-1β (IL-1β), Tumor necrosis factor-α (TNF-α), Interleukin-10 (IL-10）, the chemokines macrophage inflammatory proteins 1α and 1β (MIP-1α and 1β) in the peripheral blood and the phagocytic function of monocytes will also be detected. The current project was designed to examine the metabolic level of branched-chain amino acids in plasm and monocyte/macrophage, and its role in immune dysfunction during sepsis.

Conditions

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Sepsis Syndrome

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Sepsis with type 2 diabetes

Sepsis patients with type 2 diabetes

Metabolic level of BCAAs in monocytes and macrophages

Intervention Type OTHER

Metabolic level of BCAAs in monocytes and macrophages

Sepsis without type 2 diabetes

Sepsis patients without type 2 diabetes

Metabolic level of BCAAs in monocytes and macrophages

Intervention Type OTHER

Metabolic level of BCAAs in monocytes and macrophages

Volunteers

Healthy volunteers

Metabolic level of BCAAs in monocytes and macrophages

Intervention Type OTHER

Metabolic level of BCAAs in monocytes and macrophages

Interventions

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Metabolic level of BCAAs in monocytes and macrophages

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients diagnosed with sepsis, with or without type 2 diabetes
* healthy volunteers

Exclusion Criteria

* patients with immunodeficient diseases
* patients who accept glucocorticoid or immunosuppressant
* patients with an age younger than 18 years
* patients who cannot provide the informed consent

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes