Influence of Emotions on Decision-making in Parkinson's Disease

NCT ID: NCT03342339

Last Updated: 2021-01-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-08

Study Completion Date

2020-02-20

Brief Summary

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Parkinson's disease mainly affects the dopaminergic neurons of the Substancia nigra, which project on the striatum. Neuronal death within this structure leads to a decrease in dopamine levels. Dopamine is a neurotransmitter essential to the proper functioning of the basal ganglia highly involved in the control of voluntary and involuntary movements.

It also leads to cognitive and behavioral changes. Among these changes, the investigators will mainly remember the idea of the emergence of difficulties to make the right decisions, for example at the financial, medical .... This disruption would be the result of executive dysfunction. By definition, executive functions allow us to evaluate, plan and organize our actions to achieve a goal.

Detailed Description

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Some research shows that positive emotional states are associated with greater self-confidence, greater optimism, and better regulation of our decision-making. The goal is to test whether positive emotional induction could improve decision-making in Parkinson's disease.

Listening to music would decrease anxiety levels and increase self-esteem levels. Who says Parkinson says dopamine deficiency and so the investigators can think that the investigators can help patients by inducing a positive emotion through musical stimulation.

All participants will be subject to emotional induction. They will be divided into two different conditions: either they will be induced in a positive state, or they will be maintained in a neutral state. For this, video clips (positive or neutral) containing music will be presented. Immediately after the presentation of the video, participants will have to perform the Iowa Gambling Task test. This is a sequential task to evaluate decision-making capabilities.

Conditions

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Parkinson Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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patients with Parkinson's disease

1. cognitive examination : mini mental test of Parkinson, Hospital Anxiety and Depression Scale, 5 words by Dubois, fast test frontal assessment, Trail Making Test
2. viewing of video : scale of differential emotions and Positive and Negative Affect Scale
3. Test of Iowa Gambling Task

Group Type OTHER

cognitive examination

Intervention Type OTHER

mini mental test of Parkinson, Hospital Anxiety and Depression Scale, 5 words by Dubois, fast test frontal assessment, Trail Making Test

viewing of video

Intervention Type OTHER

viewing during 5 minutes scale of differential emotions and Positive and Negative Affect Scale

Iowa Gambling Task

Intervention Type OTHER

Test of Iowa Gambling Task

witnesses

1. cognitive examination : mini mental test of Parkinson, Hospital Anxiety and Depression Scale, 5 words by Dubois, fast test frontal assessment, Trail Making Test
2. viewing of video : scale of differential emotions and Positive and Negative Affect Scale
3. Test of Iowa Gambling Task

Group Type OTHER

cognitive examination

Intervention Type OTHER

mini mental test of Parkinson, Hospital Anxiety and Depression Scale, 5 words by Dubois, fast test frontal assessment, Trail Making Test

viewing of video

Intervention Type OTHER

viewing during 5 minutes scale of differential emotions and Positive and Negative Affect Scale

Iowa Gambling Task

Intervention Type OTHER

Test of Iowa Gambling Task

Interventions

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cognitive examination

mini mental test of Parkinson, Hospital Anxiety and Depression Scale, 5 words by Dubois, fast test frontal assessment, Trail Making Test

Intervention Type OTHER

viewing of video

viewing during 5 minutes scale of differential emotions and Positive and Negative Affect Scale

Intervention Type OTHER

Iowa Gambling Task

Test of Iowa Gambling Task

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of the disease carried out by a hospital doctor
* Stable treatment for two months minimum.
* Mini-Mental Parkinson \> 26
* Under dopaminergic treatment


* matched in age and sex
* Vision and hearing normal or successfully corrected
* Understand the French language
* general level in the test standard

Exclusion Criteria

* other neurological or psychiatric antecedents
* anxio-depressive symptomatology
* delusional or psychotic state


* neurological or psychiatric diseases
* anxio-depressive symptomatology
Minimum Eligible Age

50 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Centre Hospitalier Universitaire de Saint Etienne

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU de Grenoble Alpes

Grenoble, , France

Site Status

CHU de Saint Etienne

Saint-Etienne, , France

Site Status

Countries

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France

Other Identifiers

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2017-A02690-53

Identifier Type: OTHER

Identifier Source: secondary_id

1708168

Identifier Type: -

Identifier Source: org_study_id

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